|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we find that higher HNF1B expression strongly predicts better prognosis of prostate cancer, alone or together with lower EZH2 expression.
|
31636385 |
2020 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of HNF1B and ECI2 proteins were validated by immunohistochemistry and western blotting at different stages of prostate cancer development.
|
30655870 |
2019 |
|
Malignant neoplasm of prostate
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
This tumor-suppressor activity is lost when HNF1B is silenced by promoter methylation in the progression to PC.
|
27732966 |
2016 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies.
|
26214421 |
2015 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Twelve genes (BAG1, DDR1, ERBB4, ESR1, HSPD1, IGFBP2, IGFBP5, NR4A1, PAWR, PIK3CG, RAP2A, and TPD52) were found to be associated with both HNF1b and prostate cancer risk.
|
23661456 |
2013 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotype TG on 11q13 (rs7931342, T) could be related to an increased Gleason score, AG on HNF1B (rs4430796, A) could be associated with PSA increase, and TG on 17q24 (rs1859962, G) could be negatively associated with an increased BMI in Chinese men with PCa.
|
23464444 |
2012 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A mediation analysis of 9,065 PCa cases and 9,526 controls failed to produce evidence that diabetes mediates the association of the HNF1B locus with PCa risk.
|
23193118 |
2012 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk.
|
21576123 |
2011 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Some associations appear to be ancestry specific, such as HNF1B, which is associated with prostate cancer in European Americans and Latinos but not in African-Americans.
|
21459759 |
2011 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
As in studies from other populations, our findings indicate that HNF1B is also associated with prostate cancer risk in the Korean population.
|
21982019 |
2011 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
|
21499250 |
2011 |
|
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.
|
20569440 |
2010 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis.
|
20203524 |
2010 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the HNF1B variants are directly associated with both diabetes and prostate cancer, that diabetes does not mediate these gene variant-prostate cancer relationships, and the relationship between these diseases is not mediated through these gene variants.
|
19998368 |
2010 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
|
20676098 |
2010 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The examined HNF1B variants have a highly specific effect on prostate cancer risk with no apparent association with any of the other studied cancer types.
|
20526366 |
2010 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
|
19767753 |
2009 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer.
|
18696045 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
CTD_human |
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
|
18758462 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
|
18758462 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
CTD_human |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
Malignant neoplasm of prostate
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
|
17603485 |
2007 |