TCF3, transcription factor 3, 6929

N. diseases: 244; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE The Leukemia-Driving Fusion Protein TCF3-HLF Is Regulated by EP300. 31757791 2020
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Among direct targets, hijacking an HLF binding site in a MYC enhancer cluster by TCF3-HLF activates a conserved MYC-driven transformation program crucial for leukemia propagation in vivo. 31735627 2019
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Vaccines protect against TCF3/PBX1.3 but were ineffective when administered after leukemia injection, suggesting immunosuppression induced early during ALL progression. 30209120 2018
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Intriguingly, TCF3 (E2A)-HLF-positive leukemia was sensitive to PARP inhibitors. 27894958 2017
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Furthermore, pre-leukemia transcription factor 3 (PBX3) was a direct target gene of miR-144-3p. 28111340 2017
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE Characterisation of genomic translocation breakpoints and identification of an alternative TCF3/PBX1 fusion transcript in t(1;19)(q23;p13)-positive acute lymphoblastic leukaemias. 17593026 2007
CUI: C0023418
Disease: leukemia
leukemia
0.100 Biomarker disease BEFREE Lessons from the analysis of children with TCF3-PBX1 ALL could help to identify treatment components essential for this leukemia subtype. 18024406 2007
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression disease LHGDN The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. 16769578 2006
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE These findings suggest that TS-2 may have a genetic abnormality involving uncharacterized gene(s) at 19p13.3 distinct from the E2A gene and, therefore, may be useful for investigating the heterogeneity of molecular pathogenesis in leukemias with t(1;19)(q23;p13) translocation. 9494609 1998
CUI: C0023418
Disease: leukemia
leukemia
0.100 AlteredExpression disease BEFREE E2A-hepatic leukemia factor (HLF), a chimeric transcription factor created by the t(17;19), consists of the amino terminal portion of E2A proteins, including two experimentally defined transcriptional activation domains (TADs), fused to the HLF DNA binding and protein dimerization basic leucine zipper (bZIP) domain. 8639829 1996
CUI: C0023418
Disease: leukemia
leukemia
0.100 GeneticVariation disease BEFREE Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. 1386162 1992