|
Peripheral Vascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to investigate the association between the transcription factor 7-like 2 gene (<i>TCF7L2</i>) rs7903146 polymorphism and peripheral arterial disease in type 2 diabetes.
|
31775533 |
2020 |
|
Malignant neoplasm of mouth
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We observed five SNPs-rs2051526 (ETV6), rs6021247 (NFATC2), rs3757769 (SND1), rs7085532 (TCF7L2), and rs7778413 (SND1) indicating increased oral cancer risk with OR ranging from 1.61 to 34.60.
|
31452252 |
2020 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We observed five SNPs-rs2051526 (ETV6), rs6021247 (NFATC2), rs3757769 (SND1), rs7085532 (TCF7L2), and rs7778413 (SND1) indicating increased oral cancer risk with OR ranging from 1.61 to 34.60.
|
31452252 |
2020 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mice with a coronary artery disease-linked mutation in Wnt-coreceptor LRP6 (LDL receptor-related protein 6) exhibit vascular smooth muscle cell dedifferentiation and obstructive coronary artery disease, which are paradoxically associated with reduced TCF7L2 expression.
|
30567484 |
2019 |
|
Fetal Alcohol Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, we performed an in silico TCF7L2 binding site analysis for FASD mouse model data sets.
|
30398926 |
2019 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
|
30830316 |
2019 |
|
Nicotine Dependence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Habenular TCF7L2 links nicotine addiction to diabetes.
|
31619789 |
2019 |
|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that Tcf7l2, which accelerates cementum formation by activating NF-κB, has great potential in the treatment of periodontitis and provide guidance for periodontal tissue regeneration.
|
31037731 |
2019 |
|
Psoriasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Associations between single nucleotide polymorphisms for WNT7B, WNT10B, WNT16 and TCF7L2 genes and psoriasis were tested.
|
31089877 |
2019 |
|
Tachycardia, Ventricular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased nuclear β-catenin interacting with T-cell factor 4 (TCF4) affects the expression of target genes including SCN5A in ischemic heart disease, which is characterized by frequent ventricular tachycardia/fibrillation.
|
31419437 |
2019 |
|
Chronic nasopharyngitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results obtained revealed that mRNA and protein expression of β-catenin, TCF-4, and survivin was higher in NPC tissues than in CNP tissues.
|
30867651 |
2019 |
|
Carcinoma, Lewis Lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of exon 11 in TCF-4 inhibited TCF-4-induced cell growth of lung carcinoma and prolonged the survival time of Lewis lung carcinoma (LLC) tumor-bearing mice.
|
30527807 |
2019 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
|
30830316 |
2019 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
|
30830316 |
2019 |
|
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, restored TCF-4 expression rescued the inhibitory roles of miR-379 overexpression on cell proliferation, migration, and invasion.Our study for the first time demonstrated that miR-379/TCF-4 might involve in the progression of laryngeal carcinoma, and miR-379 appears to serve as a novel tumor suppressor in laryngeal carcinoma.
|
31436384 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, TCF7L2 rs290481 and INSR rs1799817 SNPs may influence the lymph node metastasis in patients with AEG.
|
31211453 |
2019 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
For instance, transcription factor 7-like 2 (TCF7L2) and proteasome 26S subunit, non-ATPase 9 (PSMD9) are two genes independently reported as contributing to T2D and SCZ, and PSMD9 to MDD as well.
|
30729689 |
2019 |
|
Adenocarcinoma of the gastroesophageal junction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that TCF7L2 rs290481 (T > C) and INSR rs1799817 (G > A) polymorphisms were associated with the increased susceptibility of AEG (P = .007 and 0.004 for TCF7L2 rs290481 in TC vs TT and TC/CC vs TT models, and P = .040 for INSR rs1799817 in GA/AA vs GG model).
|
31211453 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway.
|
30551418 |
2019 |
|
Nasopharyngeal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results obtained revealed that mRNA and protein expression of β-catenin, TCF-4, and survivin was higher in NPC tissues than in CNP tissues.
|
30867651 |
2019 |
|
Fetal Alcohol Spectrum Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Further, we performed an in silico TCF7L2 binding site analysis for FASD mouse model data sets.
|
30398926 |
2019 |
|
Experimental Organism Basal Cell Carcinoma
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
LUCAT1 increased stem-like properties of BCCs and stemness of BCSCs by competitively binding miR-5582-3p with TCF7L2 and enhancing the Wnt/β-catenin pathway.
|
31300015 |
2019 |
|
Carcinoma, Basal Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
LUCAT1 increased stem-like properties of BCCs and stemness of BCSCs by competitively binding miR-5582-3p with TCF7L2 and enhancing the Wnt/β-catenin pathway.
|
31300015 |
2019 |
|
Cleft Palate
|
0.010 |
Biomarker
|
disease |
BEFREE |
The methylation status of enhancer regions of HDAC4, PDGFRB, and TCF7L2, involved in the regulation of the EMT during palatal fusion, may enlighten the development of novel epigenetic biomarkers in the treatment of cleft palate.
|
29608334 |
2018 |
|
Kidney Calculi
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study was conducted to explore the role of Human Transcription Factor-7 like-2 (TCF7L2) β-defensin (DEFB1) and CD14 gene polymorphism in development and progression of nephrolithiasis.
|
29959006 |
2018 |