|
Acute lymphocytic leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
This identified 52 somatic non-synonymous mutations in 32 genes, many of which were novel, including the transcriptional coactivators CREBBP and NCOR1, the transcription factors ERG, SPI1, TCF4 and TCF7L2, components of the Ras signalling pathway, histone genes, genes involved in histone modification (CREBBP and CTCF), and genes previously shown to be targets of recurring DNA copy number alteration in ALL.
|
21390130 |
2011 |
|
Acute lymphocytic leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway.
|
30551418 |
2019 |
|
Adenocarcinoma
|
0.310 |
Biomarker
|
group |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenocarcinoma
|
0.310 |
Biomarker
|
group |
BEFREE |
Furthermore, there was a significant difference in TCF-4 localization patterns between squamous cell carcinomas and adenocarcinomas (P < 0.05).
|
15667799 |
2005 |
|
Adenocarcinoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
|
Adenocarcinoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
|
Adenocarcinoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
|
29471430 |
2018 |
|
Adenocarcinoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Adenocarcinoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Adenocarcinoma of the gastroesophageal junction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that TCF7L2 rs290481 (T > C) and INSR rs1799817 (G > A) polymorphisms were associated with the increased susceptibility of AEG (P = .007 and 0.004 for TCF7L2 rs290481 in TC vs TT and TC/CC vs TT models, and P = .040 for INSR rs1799817 in GA/AA vs GG model).
|
31211453 |
2019 |
|
Adenocarcinoma, Basal Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenocarcinoma, Oxyphilic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenocarcinoma, Tubular
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
|
21892161 |
2011 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk.
|
18478343 |
2008 |
|
Adenoma
|
0.030 |
AlteredExpression
|
group |
LHGDN |
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
|
18268006 |
2008 |
|
Adenoma
|
0.030 |
Biomarker
|
group |
BEFREE |
Knockout of TCF-4 suppresses growth and maintenance of crypt stem cells, whereas knockout of TCF-1 leads to adenomas.
|
19749792 |
2009 |
|
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Adenomatous Polyposis Coli
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
In colon carcinoma cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]).
|
10021369 |
1999 |
|
Adenomatous Polyposis Coli
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here, we assessed whether endogenous progastrin, encoded by a target gene of this complex, was in turn able to regulate beta-catenin/Tcf-4 activity in adenomatous polyposis coli (APC)-mutated cells, and we analyzed the impact of topical progastrin depletion on intestinal tumor growth in vivo.
|
17920061 |
2007 |
|
Adenomatous Polyposis Coli
|
0.050 |
Biomarker
|
disease |
BEFREE |
A proportion of APC wild-type colon carcinomas and melanomas also contains constitutive nuclear Tcf-4/beta-catenin complexes as a result of dominant mutations in the N terminus of beta-catenin that render it insensitive to downregulation by APC, GSK3 beta, and Axin/Conductin.
|
10549354 |
2000 |
|
Adenomatous Polyposis Coli
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Expression of APC N1026S in SW480 and DLD-1 cells did not diminish beta-catenin/Tcf-4-mediated transcription as effectively as APC wild-type.
|
18166348 |
2008 |
|
Adenomatous Polyposis Coli
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The activation of the pathway was mainly due to the mutation of adenomatous polyposis coli (APC) or beta-catenin, and Tcf-4 was highly expressed in these cell lines with upregulated signaling.
|
12460462 |
2002 |
|
Adenovirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Either TCF7L2DN adenovirus infection or <i>Isl1</i> knockdown attenuated GLP-1-stimulated β-catenin S675 phosphorylation in INS-1 832/13 cells or mouse islets and GLP-1 stimulated insulin secretion in INS-1 832/13 or MIN6 cells.
|
29678908 |
2018 |
|
Adenovirus Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In hepatocytes, TCF7L2DN adenovirus infection led to stimulated expression of genes that encode lipogenic transcription factors and lipogenic enzymes, while estradiol (E2) treatment attenuated the stimulation, associated with Wnt-target gene activation.
|
31589598 |
2019 |
|
Adrenoleukodystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, real-time PCR analysis revealed that β-catenin and TCF-4 increased mRNA levels of ABCD2 in both a hepatocellular carcinoma cell line and primary fibroblasts from an X-ALD patient.
|
23437103 |
2013 |