Colorectal Carcinoma
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Insulin Resistance
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Decreased waist to hip ratio
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Alzheimer's Disease
|
0.110 |
AlteredExpression
|
disease |
BEFREE |
Alzheimer disease-linked Presenilin-1 (PS1) is a negative modulator of beta-catenin/Tcf-4 activity.
|
16306047 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
|
17503332 |
2007 |
Crohn's disease of the ileum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Crohn's ileitis is associated with a reduced expression of the Wnt signalling pathway transcription factor T-cell factor 4 (TCF4), which is regulating Paneth cell differentiation.
|
18810765 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Type 2 diabetes risk variants in TCF7L2, CDKAL1, SLC30A8, HHEX/IDE, CDKN2A/2B, IGF2BP2, FTO, TCF2, PPARG, KCNJ11, and WFS1 loci were genotyped in a cohort of women with a history of GDM (n = 283) and glucose-tolerant women of the population-based Inter99 cohort (n = 2446).
|
18984664 |
2009 |
Hyperglycemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups.
|
20682688 |
2010 |
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polycystic ovary syndrome is not associated with polymorphisms of the TCF7L2, CDKAL1, HHEX, KCNJ11, FTO and SLC30A8 genes.
|
22443257 |
2012 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms.
|
28067832 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
Biomarker
|
disease |
BEFREE |
T2D was associated with TCF7L2 and FTO but not HLA, and the risk conferred by sweetened beverages appeared modified by FTO (OR 1.45, 95% CI 1.21-1.73 in non-carriers).
|
30656477 |
2020 |
Colorectal Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
T-cell factor-4 frameshift mutations occur frequently in human microsatellite instability-high colorectal carcinomas but do not contribute to carcinogenesis.
|
12036905 |
2002 |
Colorectal Neoplasms
|
0.490 |
AlteredExpression
|
group |
BEFREE |
TCF-4 and beta-catenin form a transcription complex, which is important for both maintenance of normal epithelium and development of colorectal tumors.
|
12036905 |
2002 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
T cell factor-4 (TCF-4) plays an important role in development and carcinogenesis.
|
15667799 |
2005 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TCF-4 mRNA expression was significantly higher in tumors with moderate-poor cell differentiation than in well differentiated tumors (P < 0.05).
|
15667799 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Transcription factor 7-like 2 (TCF7L2) variants have been identified to be strongly associated with type 2 diabetes risk, probably due to decreased beta-cell function.
|
17519421 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 variants were associated with type 2 diabetes in a Europid case-control population and in families, but not in African Americans.
|
17579832 |
2007 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TCF-4 expression differed relative to tumor, node metastasis (TNM) stage (P = .024).
|
17768662 |
2007 |
Neoplasm Metastasis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
TCF-4 expression differed relative to tumor, node metastasis (TNM) stage (P = .024).
|
17768662 |
2007 |
Malignant neoplasm of lung
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 variation also was associated with lung cancer incidence in whites but not blacks, but residual confounding by smoking may be present.
|
18268068 |
2008 |
Carcinoma of lung
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 variation also was associated with lung cancer incidence in whites but not blacks, but residual confounding by smoking may be present.
|
18268068 |
2008 |