TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02). 22461567 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE Transcription factor 7-like 2 (TCF7L2) is a gene that is related to the development of diabetes. 18806947 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE TCF7L2 type 2 diabetes susceptibility alleles are associated with islet autoantibody-negative but not autoantibody-positive new onset diabetes in young patients. 19050058 2009
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance. 19806338 2010
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE TCF7L2 diabetes risk variants, either as single-nucleotide polymorphisms or as haplotypes, detrimentally influence β-cell function and might play a role in determining the metabolic phenotype of patients with newly diagnosed type 2 diabetes. 21159844 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE TCF7L2 therefore appears as a genetic link between diabetes and atherosclerosis. 21423583 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes. 26525881 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 AlteredExpression disease BEFREE TCF7L2 is a transcription factor in the canonical Wnt pathway, involved in multiple disorders, including diabetes, cancer and psychiatric conditions. 26934194 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated. 28299838 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susceptibility. 31312258 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE After adjusting for known confounding factors, we found a significant association between TCF7L2/rs122555372 and C-peptide (β = -0.76, P = .005) in patients with diabetes and between fasting glucose (β = 2.05, P = .039) and homeostatic model assessment of β-cell function (β = -32.14, P = .025) levels in individuals without diabetes. 28101933 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE All subjects were genotyped for the previously described TCF7L2 diabetes risk variants. 18702948 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility. 19169495 2008
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE An interaction (p = 0.048) between TCF7L2 variants and coffee intake was apparent, with an inverse association between coffee and type 2 diabetes present among carriers of the diabetes risk allele (T) in rs12255372 (GG: HR 0.99 [95% CI 0.97, 1.02] per cup of coffee; GT: HR 0.96 [95% CI 0.93, 0.98]); and TT: HR 0.93 [95% CI 0.88, 0.98]). 27623947 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM. 25185853 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes. 26914832 2016
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated. 24529562 2014
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Common variants in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance. 16855264 2006
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Controlling for diabetes status, participants with the TT genotype of TCF7L2 (n= 12) performed worse on tests of attention/executive function/processing speed than those with the CC (n= 46) and CT (n= 53) genotypes, despite no between-group differences in demographic or medical variables. 22712642 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. 17181866 2006
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE Findings support an association between TCF7L2 and breast cancer and history of diabetes modifies this association for specific variants. 23085767 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits. 30419301 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. 31619789 2019
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 Biomarker disease BEFREE However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain. 29993315 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.200 GeneticVariation disease BEFREE Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%. 25058603 2014