Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02).
|
22461567 |
2012 |
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Transcription factor 7-like 2 (TCF7L2) is a gene that is related to the development of diabetes.
|
18806947 |
2009 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 type 2 diabetes susceptibility alleles are associated with islet autoantibody-negative but not autoantibody-positive new onset diabetes in young patients.
|
19050058 |
2009 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance.
|
19806338 |
2010 |
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
TCF7L2 diabetes risk variants, either as single-nucleotide polymorphisms or as haplotypes, detrimentally influence β-cell function and might play a role in determining the metabolic phenotype of patients with newly diagnosed type 2 diabetes.
|
21159844 |
2011 |
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
TCF7L2 therefore appears as a genetic link between diabetes and atherosclerosis.
|
21423583 |
2011 |
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes.
|
26525881 |
2016 |
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
TCF7L2 is a transcription factor in the canonical Wnt pathway, involved in multiple disorders, including diabetes, cancer and psychiatric conditions.
|
26934194 |
2016 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated.
|
28299838 |
2017 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susceptibility.
|
31312258 |
2019 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for known confounding factors, we found a significant association between TCF7L2/rs122555372 and C-peptide (β = -0.76, P = .005) in patients with diabetes and between fasting glucose (β = 2.05, P = .039) and homeostatic model assessment of β-cell function (β = -32.14, P = .025) levels in individuals without diabetes.
|
28101933 |
2017 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All subjects were genotyped for the previously described TCF7L2 diabetes risk variants.
|
18702948 |
2008 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility.
|
19169495 |
2008 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An interaction (p = 0.048) between TCF7L2 variants and coffee intake was apparent, with an inverse association between coffee and type 2 diabetes present among carriers of the diabetes risk allele (T) in rs12255372 (GG: HR 0.99 [95% CI 0.97, 1.02] per cup of coffee; GT: HR 0.96 [95% CI 0.93, 0.98]); and TT: HR 0.93 [95% CI 0.88, 0.98]).
|
27623947 |
2016 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
|
26914832 |
2016 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated.
|
24529562 |
2014 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Common variants in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance.
|
16855264 |
2006 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Controlling for diabetes status, participants with the TT genotype of TCF7L2 (n= 12) performed worse on tests of attention/executive function/processing speed than those with the CC (n= 46) and CT (n= 53) genotypes, despite no between-group differences in demographic or medical variables.
|
22712642 |
2012 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.
|
17181866 |
2006 |
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Findings support an association between TCF7L2 and breast cancer and history of diabetes modifies this association for specific variants.
|
23085767 |
2012 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits.
|
30419301 |
2018 |
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors.
|
31619789 |
2019 |
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain.
|
29993315 |
2018 |
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%.
|
25058603 |
2014 |