TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 AlteredExpression disease BEFREE Mice with a coronary artery disease-linked mutation in Wnt-coreceptor LRP6 (LDL receptor-related protein 6) exhibit vascular smooth muscle cell dedifferentiation and obstructive coronary artery disease, which are paradoxically associated with reduced TCF7L2 expression. 30567484 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 GeneticVariation disease GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 GeneticVariation disease BEFREE We genotyped TCF7L2 variants rs7903146, rs12255372, and rs11196205 in a cross-sectional study including 1,650 consecutive patients undergoing coronary angiography for the evaluation of established or suspected stable CAD. 21423583 2011
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 GeneticVariation disease BEFREE Moreover, we observed associations between TCF7L2 variants and the following diabetic complications: diabetic retinopathy, cardiovascular disease and coronary artery disease. 22843023 2013
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 Biomarker disease BEFREE In T2D-specific PPI networks involving 64 genes, TCF7L2 (Degree = 169) was identified as a key gene in T2D development, while in CAD-specific PPI networks involving 64 genes, HIF1A (Degree = 124), SMAD1 (Degree = 112) and SKIL (Degree = 94) were identified as key genes in the CAD development. 28595632 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 Biomarker disease BEFREE Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease. 26489464 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 GeneticVariation disease BEFREE This study aimed to evaluate the association between TCF7L2 polymorphism rs7903146 and coronary artery disease in diabetic and non-diabetic subjects. 19924244 2009
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.170 GeneticVariation disease BEFREE TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilian cohort of patients with known coronary heart disease. 19055834 2008