Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Latent autoimmune diabetes mellitus in adult
0.080 Biomarker disease BEFREE The combination of overweight and high-risk genotypes of HLA, TCF7L2, and FTO was associated with pooled relative risk (RRpooled) of 7.59 (95% CI, 5.27 to 10.93), 2.65 (95% CI, 1.97 to 3.56), and 2.21 (95% CI, 1.60 to 3.07), respectively, for LADA, compared with normal-weight individuals with low/intermediate genetic risk. 31125083 2019
Latent autoimmune diabetes mellitus in adult
0.080 GeneticVariation disease BEFREE The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA). 30456822 2019
Latent autoimmune diabetes mellitus in adult
0.080 GeneticVariation disease BEFREE Variants in the ZMIZ1 (rs12571751, p = 4.1 × 10(-5)) and TCF7L2 (rs7903146, p = 5.8 × 10(-4)) loci were strongly associated with LADA. 24906951 2014
Latent autoimmune diabetes mellitus in adult
0.080 GeneticVariation disease BEFREE The meta-analysis yielded a significant effect of TCF7L2 T allele (OR 1.28; p < 0.0001) on LADA risk without heterogeneity among Europeans. 22109281 2012
Latent autoimmune diabetes mellitus in adult
0.080 GeneticVariation disease BEFREE TCF7L2 common genetic variants of susceptibility are associated only with low GADA antibody titre in LADA patients. 20546291 2010
Latent autoimmune diabetes mellitus in adult
0.080 GeneticVariation disease BEFREE We observed increased frequencies of the TT genotype of the rs7903146 polymorphism in the TCF7L2 gene in LADA patients compared to controls (15 vs. 6%, P = 0.03). 19533015 2010
Latent autoimmune diabetes mellitus in adult
0.080 GeneticVariation disease BEFREE However, and somewhat at odds with current thinking, TCF7L2, the most strongly associated gene with T2D to date, is strongly associated with LADA, a disorder considered by the World Health Organization to be a slowly progressing form of T1D. 20007922 2010
Latent autoimmune diabetes mellitus in adult
0.080 GeneticVariation disease BEFREE Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 x 10(-7)), compared with control subjects (44.8%) and type 1 diabetic subjects (43.3%). 18310307 2008