TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 GeneticVariation disease BEFREE The strong LD existed between the 2 single nucleotide polymorphisms and haplotype T-T (rs7903146-rs290487) increased the susceptibility to DN (OR = 2.63, 95% CI = 1.31-5.25).TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to DN in Chinese Han population, but rs290487 is not. 30290587 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 GeneticVariation disease BEFREE Our results suggest that TCF7L2 gene polymorphism may contribute to the risk of DN. 26986145 2016
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 GeneticVariation disease BEFREE Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM. 25185853 2014
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 GeneticVariation disease BEFREE In our study the T allele of the rs7903146 SNP in the TCF7L2 gene confers the risk of developing diabetic nephropathy. 24574000 2014
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 Biomarker disease BEFREE This study aims to elucidate molecular interactions between activin receptor-like kinase 1 (ALK1)/Smad1 signaling pathway and transcription factor 7-like 2 (TCF7L2) in the progression of DN in vitro and in vivo. 20803090 2010
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 GeneticVariation disease BEFREE Association and interaction analyses of genetic variants in ADIPOQ, ENPP1, GHSR, PPARgamma and TCF7L2 genes for diabetic nephropathy in a Taiwanese population with type 2 diabetes. 19506043 2009
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.070 GeneticVariation disease BEFREE We also analyzed polymorphisms within the genes encoding for the renin-angiotensin system that were considered as candidate genes for diabetic nephropathy susceptibility and the transcription factor 7-like 2 (TCF7L2) as a candidate for type II diabetes, in a large cohort of a Japanese population. 17653210 2007