TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Disease: Liver diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.010 GeneticVariation group BEFREE The TCF7L2 CT/TT genotype was more frequent in NAFLD and predicted the presence and severity of liver disease, of beta-cell dysfunction, of reduced incretin effect and hepatic insulin resistance in NASH; it also modulated postprandial hepatocyte apoptosis, lipoproteins, and adipokine profiles in both groups. 19105201 2009
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.010 GeneticVariation group LHGDN TCF7L2 polymorphism predisposes to NAFLD and significantly impacts liver injury, glucose homeostasis, and postprandial lipoprotein and adipokine responses to fat ingestion. 19105201 2009