TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 Biomarker phenotype BEFREE Effect of miR-212 targeting TCF7L2 on the proliferation and metastasis of cervical cancer. 28165569 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 Biomarker phenotype BEFREE Together, our results establish the LIN28B/TCF7L2 interaction loop as a central mediator of cancer stemness driven by proinflammatory processes during progression and metastasis, possibly offering a new therapeutic target for generalized interventions in advanced cancers. 25744721 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 AlteredExpression phenotype BEFREE In addition, a qRT-PCR analysis of TCF7L2 mRNA levels in tumor samples revealed significantly lower levels in patients with metastasis when compared with those without metastasis. 20095040 2010
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 Biomarker phenotype BEFREE In a rat model for breast cancer it has been shown that metastasis-inducing DNA (Met-DNA) sequesters the endogenous inhibitory Tcf-4 and thereby promotes transcription of the secreted extracellular matrix glycophosphoprotein, osteopontin, the direct effector of metastasis in this model system. 18289012 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 AlteredExpression phenotype BEFREE TCF-4 expression differed relative to tumor, node metastasis (TNM) stage (P = .024). 17768662 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.060 AlteredExpression phenotype BEFREE Furthermore, hTcf-4 gene expression was closely associated with tumor capsule status and intrahepatic metastasis of HCC. 12378619 2002