|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results provide evidence that the T risk allele in TCF7L2 rs7903146 is associated with failure in early postprandial glycemic control and requirement of insulin therapy in women with gestational diabetes mellitus, even after adjusting for confounding factors such BMI and age.
|
31546272 |
2019 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Relationship of lactation, BMI, and rs12255372 TCF7L2 polymorphism on the conversion to type 2 diabetes mellitus in women with previous gestational diabetes.
|
30614312 |
2019 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Liver fat content was not associated with either a history of GDM or a TCF7L2 risk genotype.
|
30419301 |
2018 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The genetic variant rs7903146 (C > T) in TCF7L2 gene showed a strong association with GDM risk (OR: 2.56; 95% CI: [1.24-5.29]).
|
29325775 |
2018 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In addition, we confirmed three variants, rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs4506565 (TCF7L2), that had previously been significantly associated with GDM risk.
|
29947923 |
2018 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In summary, TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 might be associated with GDM risks.
|
28277135 |
2017 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The relationship between TCF7L2 polymorphism and GDM occurrence was evaluated by pooled odds ratios.
|
28002648 |
2017 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Overall GDM was associated with rs10830963(MTNR1B), rs7903146(TCF7L2), and rs1801278(IRS1), but only rs7903146(TCF7L2) and rs1801282(PPARG) were significant in Asian populations.
|
27468700 |
2016 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The association between TCF7L2 rs7903146 polymorphism and GDM risk was assessed by pooled odd ratios (ORs) using five gene models (dominant, recessive, homozygote, heterozygote, and allele).
|
27058589 |
2016 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This finding suggests that TCF7L2 rs290487, and rs7094463 were a potential clinical value for the prediction of GDM.
|
27465520 |
2016 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146, rs12243326; P=2.16 x 10(-06); OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892, rs163184, rs2237897; P=1.98 x 10(-05); OR=0.55).
|
25973943 |
2015 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In the healthy and GDM pregnant women groups, the A-allele frequencies (95% CI) of FTO polymorphisms rs8050136 and rs9939609 were 39% (34-44%); 38% (33-43%) and 40% (35-45%); 41% (36-46%), respectively; and the T-allele frequencies of TCF7L2 polymorphisms rs12255372 and rs7903146 were 30% (26-35%), 32% (27-37%) and 29% (25-34%), 36% (31-41%), respectively.
|
26102344 |
2015 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Metabolic, hormonal characteristics and genetic variants of TCF7L2 associated with development of gestational diabetes mellitus in Mexican women.
|
24639413 |
2014 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The meta-analysis suggests that TCF7L2 rs7903146 genetic polymorphism was associated with increased risk of gestational diabetes mellitus.
|
23855352 |
2013 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Additionally, risk variants rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR, rs7903146 of TCF7L2 and rs11708067 of ADCY5 showed nominally significant associations with GDM (OR range from 1.25 to 1.30).
|
23761423 |
2013 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The minor alleles of rs7903146 (TCF7L2), rs12255372 (TCF7L2), rs1799884 (-30G/A, GCK), rs5219 (rs5219" genes_norm="3767">E23K, KCNJ11), rs7754840 (CDKAL1), rs4402960 (IGF2BP2), rs10830963 (MTNR1B), rs1387153 (MTNR1B) and rs1801278 (rs1801278" genes_norm="3667">Gly972Arg, IRS1) were significantly associated with a higher risk of GDM.
|
23690305 |
2013 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Transcription factor 7-like 2 gene polymorphisms and gestational diabetes mellitus.
|
22524208 |
2012 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These polymorphisms were in or near the following genes: TCF7L2 (rs7903146), MTNR1B (rs10830963), IGF2BP2 (rs4402960), KCNJ11 (rs5219), CDKAL1 (rs7754840), KCNQ1 (rs2237892 and rs2237895) and GCK (rs4607517); while no association was found for PPARG with GDM risk.
|
23029294 |
2012 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The association of TCF7L2 haplotypes with T2D and gestational diabetes but not with PCOS was confirmed.
|
22480428 |
2012 |
|
Gestational Diabetes
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of transcription factor 7-like 2 (TCF7L2) in fat and placental tissue from women with gestational diabetes.
|
21855162 |
2011 |
|
Gestational Diabetes
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
No interaction was observed between TCF7L2 and HLA-DQB1*0602, which was shown to be negatively associated with gestational diabetes in mothers born in Sweden (P = 0.010).
|
21672010 |
2011 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
|
Gestational Diabetes
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups.
|
20682688 |
2010 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Compared with controls (men and women combined), GDM was associated with rs7756992 and rs7754840 (OR 1.55, 95% CI 1.34-1.79, p = 4.17 x 10(-9)) in CDKAL1; rs10811661 (OR 1.49, 95% CI 1.29-1.72, p = 1.05 x 10(-7)) in the CDKN2A-CDKN2B region; rs1111875 (OR 1.27, 95% CI 1.09-1.49, p = 0.003), rs5015480, and rs7923837 in HHEX; rs4402960 (OR 1.18, 95% CI 1.01-1.38, p = 0.03) in IGF2BP2; rs13266634 (OR 1.24, 95% CI 1.07-1.43, p = 0.005) in SLC30A8; and rs7903146 (OR 1.58, 95% CI 1.03-2.43, p = 0.038) in TCF7L2.
|
19002430 |
2009 |
|
Gestational Diabetes
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The TCF7L2 rs7903146 variant is associated with an increased risk of gestational diabetes mellitus in Scandinavian women.
|
17342473 |
2007 |