TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Disease: Impaired glucose tolerance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE When challenged with a high-fat diet, conditional deletion of TCF7L2 in adipocytes led to impaired glucose tolerance, impaired insulin sensitivity, promoted weight gain, and increased adipose tissue mass. 30948248 2019
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Inactivation of TCF7L2 protein by removing the high-mobility group (HMG)-box DNA binding domain in mature adipocytes in vivo leads to whole-body glucose intolerance and hepatic insulin resistance. 29317436 2018
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Transgenic mice in which Tcf7l2 was selectively inactivated in their pancreatic pericytes exhibited impaired glucose tolerance due to compromised β-cell function and glucose-stimulated insulin secretion. 29246974 2018
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Interestingly, the persistent overexpression of Tcf7l2 in non-pancreatic tissues results in a significant worsening in glucose tolerance in vivo, indicating that Tcf7l2 overexpression in beta cells does not account for the glucose intolerance in the Tcf7l2 overexpression mouse model. 25398947 2015
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 AlteredExpression phenotype BEFREE Finally, haploinsufficiency of TCF7L2 in mice displayed higher glucose levels and impaired glucose tolerance, which were rescued by hepatic expression of a nuclear isoform of TCF7L2 at the physiological level. 23028378 2012
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE Confirming these observations, transgenic mice harboring multiple Tcf7l2 copies and overexpressing this gene display reciprocal phenotypes, including glucose intolerance. 21673050 2011
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE Despite no associations between incidence of glucose intolerance and SNPs of the TCF7L2 gene in Japanese-Brazilians, we found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of the CC genotype. 21399856 2011
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE Diabetes-associated variants in CDKAL1, CDKN2B, HHEX/IDE, IGF2BP2, KCNJ11, SLC30A8 and TCF7L2 are associated with physiological alterations leading to T2DM, such as glucose intolerance, impaired insulin secretion or insulin resistance, supporting their role in the disease aetiology. 19082521 2009
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE In the total population, the TCF7L2 and IGF2BP2 variants most strongly associated with increased risk for type 2 diabetes/IGT and increased AUC for glucose, while the CDKAL1 polymorphism associated with decreased AUC for insulin. 19258437 2009
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 Biomarker phenotype BEFREE Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. 19351735 2009
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance. 17593304 2007
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.100 GeneticVariation phenotype BEFREE Common variants in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance. 16855264 2006