TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE The presence of the rs12255372 and rs7903146 TCF7L2 gene variants plays an important role in the development of T2DM among individuals with MS. 29971604 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE The results show that the genotype-phenotype for CC, CT/TT of TCF7L2 gene polymorphism correlated with body mass index and waist circumference in MetSyn and MetSyn + T2D subjects (<i>r</i> = -0.949 and <i>r</i> = -0.963, respectively). 28465699 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE In conclusion, the TCF7L2 rs7903146 polymorphism influences MetS risk, which is augmented by both gender and dietary SFA intake, suggesting novel gene-diet-gender interactions. 21543200 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE SNP in the TCF7L2 gene are associated with differences in insulin secretion, blood pressure, blood lipids and coagulation in MetS patients, and may be modulated by SFA in plasma or IR. 21115178 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE The two markers located within the TCF7L2 gene showed strong associations with T2D (rs7903146, T allele, odd ratio (OR) = 1.76, p = 0.001 and rs12255372, T allele, OR = 1.78, p = 0.002), but did not show significant association with MS. 20503258 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease GWASDB A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease GWASCAT A genome-wide association study of the metabolic syndrome in Indian Asian men. 20694148 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE In summary, high (n-6) PUFA intakes (> or = 6.62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease. 19141698 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). 18853134 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.180 GeneticVariation disease BEFREE Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys. 17226113 2007