TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 AlteredExpression disease BEFREE β-Catenin/Tcf7l2-dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer. 31392276 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 Biomarker disease BEFREE We identified two regions that specifically bind the β-catenin/TCF-4 complex in vitro and in vivo, identifying HMGA1 as an immediate target of the β-catenin/TCF-4 signalling pathway in colon cancer. 22961697 2013
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 GeneticVariation disease BEFREE The results showed that TCF7L2 polymorphism was associated with breast cancer (Homogeneous model: OR=1.17, 95%CI=1.02-1.35, I (2) =21.8%, p for heterogeneity=0.276; Heterogeneous model: OR=1.11, 95%CI=1.03-1.20, I (2) =0.0%, p for heterogeneity=0.543), prostate cancer (Homogeneous model: OR=0.89, 95%CI=0.84-0.96, I (2) =0.0%, p for heterogeneity=0.640; Heterogeneous model: OR=0.89, 95%CI=0.84-0.95, I (2) =0.0%, p for heterogeneity=0.871), and colon cancer (Heterogeneous model: OR=1.15, 95%CI=1.01-1.31, I (2) =0.0%, p for heterogeneity=0.658), but not with colorectal cancer, lung cancer, and ovarian cancer. 23951231 2013
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 GeneticVariation disease BEFREE These data suggest that colon cancer risk associated with the rs7903146 TCF7L2 polymorphism is modified by use of aspirin/NSAIDs. 18398040 2008
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 GeneticVariation disease BEFREE Subjects who were initially cancer-free and carrying certain genetic variants of TCF7L2, most notably the T allele of rs7903146, have an increased risk of colon cancer. 18268068 2008
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 Biomarker disease BEFREE Nuclear beta-catenin forms a transcription complex with TCF-4, which is implicated in colon cancer development and progression. 17909039 2007
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 Biomarker disease BEFREE These results delineate a novel role for MSI+TCF4 in leukemia and colon cancer progression. 15905022 2006
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.080 Biomarker disease BEFREE Recently, the role of TCF-4 has been described in colon cancer and other cancers. 15667799 2005