Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that CC-122 inhibits HCC tumor growth through downregulation of the oncogenic TCF-4 J isoform.
|
31352197 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
|
31666105 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that KIFC1, activated by TCF-4, functions as an oncogene and promotes HCC pathogenesis through regulating HMGA1 transcriptional activity and that KIFC1 is a potential therapeutic target to enhance the paclitaxel sensitivity of HCC.
|
31340839 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of TCF7L2 in MALAT1-overexpressing cells and HCC cell lines affected their metabolism and abolished their tumorigenic potential, suggesting that the effects of MALAT1 on glucose metabolism are essential for its oncogenic activity.
|
30914432 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The transcription factor 7 like 2‑binding protein TIP5 activates β‑catenin/transcription factor signaling in hepatocellular carcinoma.
|
29620186 |
2018 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the contrary, the transcription factor (TCF-4) enhanced H3K27 acetylation and direct transcription factor for Linc00441 was responsible for the upregulation of Linc00441 in HCC.
|
28300839 |
2017 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-139 regulates the proliferation and invasion of hepatocellular carcinoma through the WNT/TCF-4 pathway.
|
24190507 |
2014 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCF-4 isoforms (TCF-4J and K) activated different downstream target genes in HCC.
|
23651211 |
2013 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, real-time PCR analysis revealed that β-catenin and TCF-4 increased mRNA levels of ABCD2 in both a hepatocellular carcinoma cell line and primary fibroblasts from an X-ALD patient.
|
23437103 |
2013 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The functional role of the TCF-4 isoforms was evaluated in OUMS-29 (an immortalized hepatocyte-derived) and HAK-1A (a well-differentiated HCC) cell lines using stable clones overexpressing the TCF-4 isoforms.
|
23648141 |
2013 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aim to evaluate the impact of TCF7L2 gene on the susceptibility of HD and hepatocellular carcinoma (HCC) in a Chinese Han population.
|
23558246 |
2013 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SxxSS motif of T-cell factor-4 isoforms modulates Wnt/β-catenin signal activation in hepatocellular carcinoma cells.
|
23562475 |
2013 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, strong nuclear TCF4 expression was associated with tumor grade and stage in HCC.
|
23030478 |
2013 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified 14 novel TCF-4 isoforms from four HCC cell lines.
|
21256126 |
2011 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our present findings strongly suggest mutations of beta-catenin as well as over expression of beta-catenin and Tcf-4 gene activate the Wnt pathway in HCC independently with the target gene most likely to be C-myc.
|
14687479 |
2003 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On analyzing the relationship between alterations of beta-catenin or Tcf-4 and C-myc or Cyclin D1 expression, we found that mutations of beta-catenin, as well as overexpression of beta-catenin or the Tcf-4 gene were independently correlated with C-myc gene overexpression in HCC.
|
12603528 |
2003 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma.
|
12378619 |
2002 |