TCF21, transcription factor 21, 6943

N. diseases: 143; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0156344
Disease: Endometriosis of ovary
Endometriosis of ovary
0.010 Biomarker disease BEFREE These cytokines, periostin, and TCF21 colocalized in the stroma of OE and DIE. siRNA against human TCF21 gene suppressed periostin expression. 31610174 2020
CUI: C0856953
Disease: Stress induced hyperglycaemia
Stress induced hyperglycaemia
0.010 Biomarker disease BEFREE Following bariatric surgery, the impact of stress induced hyperglycemia is primarily on POD 0 in non-diabetics whereas the effect extends into POD 1 for diabetics. 31757437 2020
CUI: C3888088
Disease: SMITH-MCCORT DYSPLASIA 1
SMITH-MCCORT DYSPLASIA 1
0.010 Biomarker disease BEFREE <b>Objective:</b> To better understand how TCF21 affects SMC phenotype, we sought to investigate the possible mechanisms by which it regulates the lineage determining myocardin (MYOCD)-serum response factor (SRF) pathway. 31815603 2020
CUI: C0011206
Disease: Delirium
Delirium
0.010 Biomarker disease BEFREE During postoperative POD 1 to POD 7, the incidence of delirium is lower in the DEX group than that in the control group. 30948695 2019
CUI: C0020625
Disease: Hyponatremia
Hyponatremia
0.010 Biomarker phenotype BEFREE In binary logistic regression analysis, age >60 years (odds ratio [OR], 2.22; 95% confidence interval [CI], 1.16-4.26; P = 0.017), the nadir sodium concentration on POD 1-2 (OR, 0.88; 95% CI, 0.77-0.99; P = 0.034), and operation time (OR, 1.01; 95% CI, 1.00-1.02; P = 0.018) were independent risk factors for delayed hyponatremia after endoscopic transsphenoidal pituitary surgery. 30465961 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute
0.010 GeneticVariation disease BEFREE LRV harvest was an independent risk factor for AKI at POD1 and POD3, but not thereafter. 30322713 2019
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.010 Biomarker disease BEFREE Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia. 31312357 2019
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.010 Biomarker disease BEFREE In the present study, we define clinical stratification of HGSC tumors through the establishment of standard operating procedures for immunohistochemistry and histochemistry based detection of a panel of biomarkers including TCF21, E-cadherin, PARP1, Slug, AnnexinA2, and hyaluronan. 30857227 2019
Respiratory Distress Syndrome, Adult
0.010 AlteredExpression disease BEFREE Serum CC16 levels on POD1 increased significantly from the pretransplant state in the ARDS group but not in the non-ARDS group. 31111072 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 GeneticVariation disease BEFREE SOFA scores at POD 1-7 can effectively predict the incidence of sepsis and 30-day mortality in liver transplant patients on the basis of CRP and PCT. 30721450 2019
Secondary malignant neoplasm of lung
0.010 Biomarker disease BEFREE Further, Kisspeptin 1 (KISS1) was identified as a TCF21 downstream effector responsible for miR-3648-mediated BC invasion and lung metastasis. 31071528 2019
CUI: C0162429
Disease: Malnutrition
Malnutrition
0.010 Biomarker disease BEFREE The hydration index on POD1 was significantly higher in patients who experienced major complications than in uncomplicated patients (P=0.020 and P=0.025 for CDC and CCI, respectively).At a linear regression model, age (β=0.14, P=0.035), sex female (β=0.40, P<0.001), BMI (β=0.30, P<0.001), and malnutrition (β=0.14, P=0.037) were independent predictors of postoperative ECW. 31592889 2019
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma
0.010 AlteredExpression disease BEFREE <b>NEW & NOTEWORTHY</b> Transcription factor 21 (TCF21) is downregulated in cholangiocarcinoma (CCA) tissues or cells. 30920845 2019
Congenital contractural arachnodactyly
0.010 AlteredExpression disease BEFREE TCF21 was significantly downregulated in CCA tissues or cell lines. 30920845 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 Biomarker disease BEFREE Tcf21 was also examined for its effects by adeno-associated viruses serotype 6 (AAV6)-mediated Tcf21 gene transfer into cultured activated HSCs and mice with carbon tetrachloride- or methionine-choline deficient diet-induced liver fibrosis. 31549421 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 GeneticVariation disease BEFREE SOFA scores at POD 1-7 can effectively predict the incidence of sepsis and 30-day mortality in liver transplant patients on the basis of CRP and PCT. 30721450 2019
CUI: C0341742
Disease: Acute retention of urine
Acute retention of urine
0.010 Biomarker phenotype BEFREE Comparison of urinary catheter removal on POD 1 versus POD 3 demonstrated no significant difference in rate of urinary retention (RR 1.36, 95%CI 0.83-2.21, P = 0.22); however, compared to POD 5, rates of AUR were significantly higher (RR 2.58, 95%CI 1.51-4.40, P = 0.0005). 31707560 2019
CUI: C0405580
Disease: Adrenal cortical hypofunction
Adrenal cortical hypofunction
0.010 Biomarker disease BEFREE Hypocortisolemia on POD1 (serum cortisol < 5 μg/dl) prompted a 7 am cortisol level measurement on POD 2 (POD2). 30835697 2019
CUI: C0520909
Disease: Postoperative Nausea and Vomiting
Postoperative Nausea and Vomiting
0.010 Biomarker phenotype BEFREE Children receiving acupuncture plus antiemetic therapy had less risk of developing nausea during phase I and II recovery, but there was no difference in PONV on POD 1. 30397904 2019
CUI: C0877015
Disease: Pelvic Organ Prolapse
Pelvic Organ Prolapse
0.010 Biomarker disease BEFREE To evaluate if discharge on the day of surgery (POD0) is associated with increased 30-day unanticipated healthcare encounters after major pelvic organ prolapse (POP) surgery compared to discharge on or after post-operative day 1 (POD1). 31733206 2019
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases
0.010 Biomarker group BEFREE AKI occurred more frequently in the LRV group at POD1 (5/17 vs. 4/59, p = 0.023) and POD3 (5/17 vs. 3/59, p = 0012), with no difference in CKD between groups (2/11 vs. 5/33 at 3 months, p = 0.99). 30322713 2019
CUI: C2347761
Disease: Childhood Myelodysplastic Syndrome
Childhood Myelodysplastic Syndrome
0.010 Biomarker disease BEFREE Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia. 31312357 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.010 Biomarker phenotype BEFREE Administration of adenovirus-shRNA-JAK2 on POD 1 reduced mechanical allodynia and downstream STAT activation. 31454541 2019
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME
0.010 Biomarker group BEFREE Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia. 31312357 2019
CUI: C3900098
Disease: Adult Myelodysplastic Syndrome
Adult Myelodysplastic Syndrome
0.010 Biomarker disease BEFREE Promoter methylation of the candidate tumor suppressor gene TCF21 in myelodysplastic syndrome and acute myeloid leukemia. 31312357 2019