Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In humans, TCF21 expression inhibits risk for CAD.
|
31815603 |
2020 |
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, TCF21 expression was strongly associated with SMC phenotypic modulation in diseased human coronary arteries, and higher levels of TCF21 expression were associated with decreased CAD risk in human CAD-relevant tissues.
|
31359001 |
2019 |
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression.
|
31014396 |
2019 |
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In contrast to TCF21 which is protective toward CAD, SMAD3 expression in HCASMC was shown to be directly correlated with disease risk.
|
30307970 |
2018 |
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that TCF21 can cooperate with AHR to activate an inflammatory gene expression program that is exacerbated by environmental stimuli, and may contribute to the overall risk for CAD.
|
28481916 |
2017 |
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Functional rs12190287 polymorphisms located within the 3' untranslated region (3'-UTR) of TCF21 were associated with a risk of coronary heart disease in the European and Eastern populations.
|
28346832 |
2017 |
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2).
|
28059143 |
2017 |
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data provide the first evidence for the association of miR-146a rs2910164 and TCF21 rs12190287 with CAD in an Iranian population, encouraging further research to elucidate the disease-related effects of miR-146a rs2910164.
|
26909569 |
2016 |
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Separate enrichment analyses found over-representation of TCF21 target genes among CAD associated genes, and linkage disequilibrium between TCF21 peak variation and that found in GWAS loci, consistent with the hypothesis that TCF21 may affect disease risk through interaction with other disease associated loci.
|
26020271 |
2015 |
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.
|
26020946 |
2015 |
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Together, these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2.
|
24676100 |
2014 |
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
Coronary Arteriosclerosis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression.
|
31014396 |
2019 |
Coronary Arteriosclerosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk.
|
30307970 |
2018 |
Coronary Arteriosclerosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Functional rs12190287 polymorphisms located within the 3' untranslated region (3'-UTR) of TCF21 were associated with a risk of coronary heart disease in the European and Eastern populations.
|
28346832 |
2017 |
Coronary Arteriosclerosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2).
|
28059143 |
2017 |
Coronary Arteriosclerosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population.
|
26909569 |
2016 |
Coronary Arteriosclerosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci.
|
26020271 |
2015 |
Coronary Arteriosclerosis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.
|
26020946 |
2015 |
Coronary Arteriosclerosis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Together, these data suggest that miR-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2.
|
24676100 |
2014 |
Coronary Arteriosclerosis
|
0.380 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
Coronary Arteriosclerosis
|
0.380 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |