In this study, we reported that transcription factor 21 (TCF21) inhibits cancer cell proliferation and invasion following overexpression, in vitro and in vivo.
In addition, we propose using the subtracted expression levels of the <i>TCF21/POD-1</i> genes as a predictor of overall survival (OS) in adult carcinomas and <i>TCF21-NR5A1</i> as a predictor of malignancy for pediatric tumors in patients aged <5 years.
Transcription factor 21 (TCF21) belongs to the class A of the basic helix-loop-helix family with reported functions in early lung and kidney development as well as tumor suppressor function in the malignancies of the lung and head and neck.