TCF21, transcription factor 21, 6943

N. diseases: 143; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE The Matrigel invasion assay demonstrated that TCF21 negatively regulated invasion. 30296564 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE Overexpression of TCF21 greatly inhibited the proliferation, migration, and invasion in both TE10 and KYSE510 cell lines. 29909422 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE In this study, we reported that transcription factor 21 (TCF21) inhibits cancer cell proliferation and invasion following overexpression, in vitro and in vivo. 29608330 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE Demethylation of H1299 cells by 5-aza-2'-deoxycytine (5-Aza) demonstrated that a higher level of TCF21 expression led to remarkable decreases of cell viability and invasion ability but an increase of cell apoptosis. 29086202 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 Biomarker phenotype BEFREE miR-205 expression was increased in ovarian cancer and it promoted the invasive behavior of ovarian cancer cell lines (OVCAR-5, OVCAR-8 and SKOV-3). miR-205 directly targeted TCF21, which was significantly decreased in ovarian cancer tissue. miR-205 inhibited TCF21 expression and as a consequence blunted the inhibitory effect of TCF21 on cell invasion. 28476165 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE We thus demonstrate that decreased levels of TCF21 are associated with the pathological stage, clinical stage and lymph node metastasis, indicating a poor prognosis in CRC patients; overexpression of TCF21 inhibits cell proliferation, migration and invasion in the colorectal cell lines HCT116 and HT29. 28352192 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 PosttranslationalModification phenotype BEFREE Our data revealed that TCF21 was frequently silenced by promoter hypermethylation in both tested CRC cell lines and primary CRC, and correlation analysis between methylation status and clinicopathologic parameters found that TCF21 methylation was significantly correlated with lymph node invasion (P = 0.013), while no significant correlation was found in other parameters. 26435499 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.080 AlteredExpression phenotype BEFREE Pre-miR-21 could upregulate the expression of miR-21 and downregulate the expression of TCF21, and anti-miR-21 showed the opposite effects. siRNA-TCF21 decreased the expression of the TCF21 protein, and the expression of KISS1 was downregulated in Caki-1 cells with TCF21 gene silencing. pcDNA3.1-KISS1 transfection upregulated the expression of the KISS1 protein, and the invasion ability of Caki-1 cells with KISS1 overexpression decreased markedly. 23206776 2012