Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia.
|
17192390 |
2007 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Strikingly, profiling of the T-ALLs by clinical, genomic, and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median, 2.2 years) and with a proliferation/mitosis expression signature.
|
17452517 |
2007 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the process of analyzing TCR alpha rearrangements in a patient with adult T-cell leukemia (ATL) carrying a translocation at chromosome 14q11, we found novel complex rearrangements in the Jalpha locus.
|
11776383 |
2001 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Southern blot analysis of T cell receptor (TCR) gene rearrangements has proven to be a helpful tool to establish clonality in T cell leukemias and lymphomas.
|
10516765 |
1999 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We characterized the T-cell receptor (TCR) gene rearrangements and sequences in 15 T-lineage acute lymphoblastic leukemia (T-ALL) and seven adult T-cell leukemia (ATL) samples.
|
9301688 |
1997 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human T cell leukemias with continuous V(D)J recombinase activity for TCR-delta gene deletion.
|
9379030 |
1997 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1)] and inversions [inv14(q11;q32.1)] with TCR alpha/beta loci in T-cell leukemias, such as T-prolymphocytic (T-PLL).
|
7662982 |
1995 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although rearrangements of TCR gamma chain genes were shown in single cells of 10 of 10 T-cell leukemias, no rearrangement of these genes was found in single H&RS cells from 13 consecutive patients with HD.
|
7888676 |
1995 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the decreased expression of the TCR alpha beta/CD3 complex by ATL cells plays a key role in the development of ATL, irrespective of CD4 expression.
|
8381310 |
1993 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed the viral integration of human T-cell leukemia virus-I (HTLV-I) and monoclonal rearrangement of T-cell receptor (TCR) gene in blood lymphocytes and the cutaneous infiltrated cells of nine ATL patients with various clinical features and skin eruptions.
|
1991979 |
1991 |
Leukemia, T-Cell
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Examination of the clonalities of these cell lines by the rearrangement profiles of the TCR beta-chain gene and the integration sites of the HTLV-I proviral genome, revealed that two cell lines (KK-1 and KK-5) were of real ATL cell origin.
|
1861543 |
1991 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
A deficiency in the rearrangement of proto-oncogene to TCR-alpha may result in only a minor proliferation of abnormal lymphocytes and remain in the preleukemic state of ATL or in the HTLV-I carrier state.
|
1984842 |
1991 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinically, the TCR tau delta+ leukemias represented a distinct subgroup of T-cell leukemias.
|
1826854 |
1991 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is possible that translocations in the TCR alpha locus may be involved in ATL.
|
2169336 |
1990 |
Leukemia, T-Cell
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
beta and gamma T cell receptor (TCR) gene configuration was studied in 12 patients with large granular lymphocyte T cell leukemia (LGL-leukemia).
|
2827810 |
1988 |
Leukemia, T-Cell
|
0.100 |
Biomarker
|
disease |
BEFREE |
In an attempt to more accurately define cell lineage we have analyzed cells from patients with B- or T-cell leukemia (n = 26) at various stages of maturation with probes to two additional TCR genes, TCRG and TCRA (encoding the TCR gamma and alpha chains, respectively), as well as the IG heavy chain joining region (IGHJ) and TCRB genes.
|
3464980 |
1986 |