|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicate that PDR-motif(+) TCR could be an important TCR candidate for TCR-gene immunotherapy for HLA-A24:02(+) ATL patients, provided that the CTL activities against HTLV-1 are reproduced in in vivo experiments using mouse models.
|
24389072 |
2014 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Strikingly, profiling of the T-ALLs by clinical, genomic, and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median, 2.2 years) and with a proliferation/mitosis expression signature.
|
17452517 |
2007 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the process of analyzing TCR alpha rearrangements in a patient with adult T-cell leukemia (ATL) carrying a translocation at chromosome 14q11, we found novel complex rearrangements in the Jalpha locus.
|
11776383 |
2001 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent with these results, higher levels of CAT expression were observed in cells transiently transfected with PC-IAP-LTR or a TCR enhancer compared with LS-IAP and HTLV LTRs.
|
9324293 |
1997 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We characterized the T-cell receptor (TCR) gene rearrangements and sequences in 15 T-lineage acute lymphoblastic leukemia (T-ALL) and seven adult T-cell leukemia (ATL) samples.
|
9301688 |
1997 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The absence of Ig and TCR gene rearrangements seems to be common in HD, compared with in TRBL and incipient ATLL.
|
7874004 |
1994 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cells termed SO-4 were of ATL cell origin and showed the double-negative TCR alpha beta/CD3+ T-cell phenotype.
|
7803265 |
1994 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the decreased expression of the TCR alpha beta/CD3 complex by ATL cells plays a key role in the development of ATL, irrespective of CD4 expression.
|
8381310 |
1993 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monoclonal integration of human T-cell leukemia virus type I (HTLV-I) proviral DNA and T-cell receptor C beta gene (TCR C beta) rearrangement were detected in the ATL cells, but not in the leukemic monoblasts.
|
1337297 |
1992 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed the viral integration of human T-cell leukemia virus-I (HTLV-I) and monoclonal rearrangement of T-cell receptor (TCR) gene in blood lymphocytes and the cutaneous infiltrated cells of nine ATL patients with various clinical features and skin eruptions.
|
1991979 |
1991 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The relationship between chromosome breakpoints associated with T-cell antigen receptor (TCR) genes and TCR-alpha/beta/tau/delta rearrangements of peripheral leukaemic cells in 8 Japanese patients with the acute type of adult T-cell leukaemia (ATL) was examined.
|
1659101 |
1991 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A deficiency in the rearrangement of proto-oncogene to TCR-alpha may result in only a minor proliferation of abnormal lymphocytes and remain in the preleukemic state of ATL or in the HTLV-I carrier state.
|
1984842 |
1991 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Examination of the clonalities of these cell lines by the rearrangement profiles of the TCR beta-chain gene and the integration sites of the HTLV-I proviral genome, revealed that two cell lines (KK-1 and KK-5) were of real ATL cell origin.
|
1861543 |
1991 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is possible that translocations in the TCR alpha locus may be involved in ATL.
|
2169336 |
1990 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia.
|
3025859 |
1987 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case.
|
2961364 |
1987 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the configuration and expression of the gene encoding the beta chain of the T cell receptor (TCR beta) in cell lines and primary tumor cells infected by the human T cell leukemia/lymphoma (lymphotrophic) virus type I (HTLV-I).
|
3003226 |
1986 |