|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The clinicopathologic characteristics, immunophenotype, EBV in situ hybridization, and T cell receptor (TCR) gene rearrangement of primary pulmonary NK cell lymphoma from a 73-year-old Chinese woman were investigated and the clonal status was determined using female X-chromosomal inactivation mosaicism and polymorphisms at the phosphoglycerate kinase (PGK) gene.
|
23958352 |
2013 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to investigate the clinicopathologic features, immunophenotype, T cell receptor (TCR) gene rearrangement, the association with Epstein-Barr virus (EBV) infection and p53 gene mutations of the lymphoma.
|
23557559 |
2013 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunoglobulin heavy chain (IgH) or T-cell receptor (TCR) gene rearrangement is observed in B-cell or T-cell primary vitreoretinal lymphoma, respectively.
|
22834783 |
2012 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Strikingly, this unique TCR-independent killing is induced through lymphoma MHC-I engagement.
|
21753148 |
2011 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Ig/TCR VDJ errors are also at the origin of recombinase mediated deregulated expression of a variety of proto-oncogenes in ALL, whereas in lymphoma it is increasingly clear that IgH containing translocations result from abnormalities other than VDJ errors (somatic hypermutation and/or isotype switching).
|
19731811 |
2009 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The predominant lymphoma types found in these 14 NBS children were diffuse large B cell lymphoma (DLBCL) and T cell lymphoblastic lymphoma (T-LBL/ALL), all showing monoclonal Ig/TCR rearrangements.
|
18788073 |
2008 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with early onset.
|
16959610 |
2006 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Incorporating the results of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements enabled diagnosis of lymphoma in 17 patients, including 5 of the 6 patients suspected to have NHL or an atypical lymphoid proliferation.
|
16533955 |
2006 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Five (25%) of the NK/T-cell phenotype lymphomas showed rearranged TCR gamma gene.
|
14989738 |
2004 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
EBV- TCR- lymphoma showed less necrosis (P = 0.0133) and a better 2-year survival rate (P = 0.0066) than EBV+ TCR- lymphoma.
|
15139996 |
2004 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The sequencing showed that TCR-gamma gene rearrangement of the gastrointestinal lymphomas included functional gene and pseudogene with extensive variety in the junctional regions.
|
15052681 |
2004 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Detection of a clonal T cell receptor (TCR) gene rearrangement is used in the diagnosis of primary cutaneous T cell lymphomas (CTCL) whereas chromosomal aberrations serve as a diagnostic tool for leukaemias and nodal lymphomas.
|
15086537 |
2004 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To identify such mixed-lineage lymphomas, we undertook a survey of 15 consecutive sinonasal lymphomas and found six with both a restricted KIR repertoire and a monoclonal TCR-gamma rearrangement, consistent with KIR(+) T-cell lymphomas.
|
12533686 |
2003 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Sixty cases with a confirmed histological diagnosis of a T-cell lymphoproliferative disorder and TCR gamma GR were identified in our lymphoma registry from 1995 to 2001.
|
12707372 |
2003 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Angioimmunoblastic T cell lymphoma (AILT) is a rare lymphoma that is regarded as a clinicopathologic entity but shows considerable histomorphologic diversity, variable immunophenotypes and inconsistent T cell receptor (TCR) gene rearrangement.
|
12455048 |
2003 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether CD8 independent tumor cell recognition is a property of the TCR, we used retroviral transduction to express the TIL 1383I TCR in the CD8(-) murine lymphoma, 58 alpha(-)/beta(-).
|
12594285 |
2003 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Our current knowledge on the molecular and genetic basis of neoplastic transformation of lymphoid cells resulting in clinical phenotype of malignant lymphoma is further reviewed, and basic specific molecular mechanisms of Ig/TCR gene deregulation are presented, as well as recent achievements in molecular genetic profiling of malignant lymphoma.
|
12402389 |
2002 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Similarly, in TCR transgenic lymphomas overexpression of Ras, Raf and L-myc but not Bcl-2 family proteins may be responsible for the resistance of these lymphomas to TCR-mediated apoptosis but not affect p53-mediated apoptosis.
|
10634643 |
2000 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ten of 12 lymphomas tested showed clonal immunoglobulin (Ig) heavy chain gene rearrangements in the absence of clonal T-cell receptor (TCR) gene rearrangements.
|
10492077 |
1999 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Characterization of lymphoma and gastritis areas of seven gastrectomy specimens using a T-cell receptor beta variable chain (TCR betaV) family-specific reverse transcriptase (RT)-polymerase chain reaction (PCR) assay and fluorescence-activated cell sorter (FACS) analysis revealed a local chronic and acute activation of T cells in lymphoma and an oligoclonal T-cell repertoire in gastritis and in lymphoma, partially sharing the same clones.
|
10565685 |
1999 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Southern blot analysis of T cell receptor (TCR) gene rearrangements has proven to be a helpful tool to establish clonality in T cell leukemias and lymphomas.
|
10516765 |
1999 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Characterization of the clonality of non-Hodgkin's lymphoma (NHL) by the rearranged segments of immunoglobulin heavy chain (Ig(H)) or T cell receptor (TCR) genes is not only useful in the confirmation of the diagnosis but also for the future assessment of how a secondary lymphoma, such as a recurrence or another primary lymphoma, occurs.
|
10355963 |
1999 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Southern analysis and polymerase chain reaction (PCR) were used to detect the rearranged V-D-J segment of T-cell receptor delta (TCR delta) gene from malignant cell specimens of patients with leukemia and lymphoma of T-cell lineage.
|
9209365 |
1997 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
T-cell receptor delta (TCR-delta) gene rearrangement was studied in 40 cases of acute leukaemia and lymphoma of T-cell lineage at diagnosis.
|
8756082 |
1996 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data.
|
8698315 |
1996 |