Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 GeneticVariation disease BEFREE The malignant SS clone was identified as TCR Vα2-Jα22 rearrangement without deletion at the A20 loci (6q23-27 region) in the SS case. 28296250 2018
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 Biomarker disease BEFREE The lack of clear stereotypic TCRA and TCRB CDR3 amino acid motifs would argue against involvement of a single common antigen in the pathogenesis of SS. 21410672 2011
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 Biomarker disease BEFREE Peripheral blood mononuclear cells were obtained from a patient with SS, stained with anti-T-cell receptor Vb (TCR-Vb) antibodies, and sorted by multiparameter flow cytometry. 20698843 2010
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 GeneticVariation disease BEFREE Molecular staging in MF and SS using a PCR-based method for TCR gene analysis provides additional information to histological examination. 16965425 2006
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 GeneticVariation disease BEFREE We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome. 16741518 2006
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 Biomarker disease BEFREE The authors suggest that the definitive diagnostic criteria for patients with SS should include the presence of a clonal TCR gene rearrangement. 11745245 2001
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 GeneticVariation disease BEFREE Four biopsies, from three patients, contained clonal TCR-gamma rearrangements; the four biopsies, all of which were equivocal histologically, correlated to diagnoses of mycosis fungoides (MF) or Sézary syndrome (SS). 11437940 2001
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 GeneticVariation disease BEFREE To determine if circulating Sezary cells can be classified as reactive or neoplastic based on the ability to detect the presence or absence of clonal T-cell receptor beta chain (TCR-beta) gene rearrangements by Southern blot analysis, we evaluated the peripheral blood of 25 patients: 11 patients with Sezary syndrome (SS), 11 with benign inflammatory dermatoses (BID), and three normal controls. 7492785 1995
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 Biomarker disease BEFREE The goal of our study was to molecularly diagnose CTCL, by cloning the T-cell antigen receptor beta chain (TCR-beta) gene rearrangement from the malignant T cells of a patient with Sézary syndrome, in order to generate a specific oligonucleotide probe capable of detecting CTCL cells through polymerase chain reaction (PCR) amplification. 1848269 1991
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 GeneticVariation disease BEFREE In the two "false-negative" cases of SS clonal TCR beta gene rearrangements were detected in PBL obtained during follow-up. 1655913 1991
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome
0.100 Biomarker disease BEFREE Nine patients had acute lymphoblastic leukaemia (T-ALL), nine patients had prolymphocytic leukaemia (PLL), six patients presented with a T-CLL/T-lymphocytosis syndrome, two patients had Sezary syndrome (SS) and one patient had HTLV-I positive T-cell leukaemia/lymphoma (ATLL). alpha TCR gene rearrangement could be demonstrated by the use of three available probes in only one case. 2961364 1987