|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Minimal residual disease (MRD) measured by PCR of clonal IgH/TCR rearrangements predicts relapse in T-cell acute lymphoblastic leukemia (T-ALL) and serves as risk stratification tool.
|
30552401 |
2019 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal translocations involving the TCR loci represent one of the most recurrent oncogenic hallmarks of T-cell acute lymphoblastic leukemia (T-ALL) and are generally believed to result from illegitimate V(D)J recombination events.
|
22948044 |
2012 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, molecular monitoring of minimal residual disease, by far the most reliable independent prognostic factor in T-ALL, has been highlighted in the context of Ig/TCR gene rearrangements.
|
22145858 |
2012 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Examination of the T-cell receptor gamma (TCR-γ) rearrangement in T-ALL blasts, JXG infiltrated lymph node biopsies and micro-dissected JXG histiocytes revealed an identical bi-allelic TCR-γ rearrangement in all samples, thus providing evidence for a clonal relationship between T-ALL and JXG in this case.
|
20848640 |
2011 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias.
|
16270038 |
2006 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of molecular cytogenetic and large-scale expression analysis in human T-cell acute lymphoblastic leukemias (T-ALLs), we identified and characterized a new recurrent chromosomal translocation, targeting the major homeobox gene cluster HOXA and the TCRB locus.
|
15774621 |
2005 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The overall stability of TCR gene rearrangements was higher in adult T-ALL (97%) than in childhood T-ALL (86%).
|
14576730 |
2003 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An increased frequency of complete Vbeta-Jbeta1 rearrangements was observed in TCR alphabeta+ T-ALL as compared to CD3- and TCR gammadelta+ T-ALL (33% vs 16% and 11%, respectively), and also incompletely rearranged V-D, D-D, or D-J alleles in the beta2 region occurred more frequently in TCR alphabeta+ cases than in CD3- and TCR gammadelta+ T-ALL (27% vs 15% and 18%, respectively).
|
10360387 |
1999 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The described T-ALL and the T cell line can serve as an experimental model in further studies on the regulatory elements involved in the specific deletion of the TCR-delta gene complex.
|
9379030 |
1997 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have studied the molecular characteristics of the T cell receptor (TcR) genes in 16 patients with CD7+ early T cell acute lymphoblastic leukemia (T-ALL), defined as being positive for CD7 but negative for CD3/4/8, myeloperoxidase (MPO), and CD19/20.
|
8618442 |
1996 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCR genes were invariably rearranged in T-cell ALLs (11 cases).
|
7845017 |
1995 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous analysis of the TCR genes strongly suggested the clonal origin of human T-ALL.
|
7564515 |
1995 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A human CD4- CD8- alpha beta T-cell receptor (TCR alpha beta)+ T leukemic cell line, L-KAW, was established from the peripheral blood of a 6-year-old male patient with T-cell acute lymphoblastic leukemia.
|
7543637 |
1995 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The structures of rearranged gamma-chain T-cell antigen receptor (TCR) genes were analyzed in 5 cases of T-cell acute lymphoblastic leukemia (T-ALL), in 15 cases of peripheral T-cell non-Hodgkin's lymphoma (T-NHL), in 1 case with large granular CD8 lymphocytosis, 1 case with CD8 lymphocytosis after autologous bone marrow transplantation for Hodgkin's disease, and in 2 cases with nonneoplastic diseases.
|
8025283 |
1994 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have developed a strategy based on polymerase chain reaction (PCR) for detecting all possible gamma T-cell receptor (gamma TCR) rearrangements and the most common delta TCR rearrangements found in B-lineage and T-acute lymphoblastic leukemia (T-ALL).
|
8142656 |
1994 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a small number of lines tested, the ReHF-1 protein was expressed in gamma delta lineage T cells and in a number of B cell precursor ALLs whose TCR delta locus has been rearranged.
|
7947454 |
1994 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Careful examination of all TCR genes revealed that tal-1 deletions exclusively occurred in CD3- or CD3+ T-ALL of the alpha/beta lineage with a frequency of 18% in T-ALL with one deleted TCR-delta allele, and a frequency of 34% in T-ALL with TCR-delta gene deletions on both alleles.
|
8459224 |
1993 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymerase chain reaction (PCR) was used to amplify cDNA in order to characterize normal and hybrid T-cell receptor (TCR) gene rearrangements derived from a T-cell acute lymphoblastic leukemia (T-ALL) bearing a chromosome 7 inversion.
|
8412327 |
1993 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a 10-year study of T-cell acute lymphoblastic leukemias (T-ALL) in children, we have identified five cases expressing the T-cell receptor tau delta (TCR tau delta).
|
1826854 |
1991 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The analysis of the TCR beta, -gamma, and -delta gene configurations in 23 of the 40 T-ALLs showed that: (1) the lack of TCR protein expression was due to the lack of TCR gene rearrangements only in one of nine cases; (2) five of five TCR beta+, TCR alpha- cases studied had germline TCR alpha genes (ie, no detectable TCR delta gene deletions); (3) seven of eight cases with TCR delta gene deletions expressed TCR alpha proteins, whereas in 12 of 20 of the T-ALLs with TCR beta gene rearrangements the synthesis of the corresponding protein occurred; only 2 of 16 cases with rearranged TCR delta genes expressed TCR delta chains.
|
1826223 |
1991 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The patterns of Ig and TCR genes in B-cell precursor and T-cell ALL of childhood and ALL of infancy are heterogeneous though generally distinctive.
|
1837810 |
1991 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Oligoclonal rearrangements of Ig and TCR genes were observed in two cases of B-cell precursor ALL and in one case of T-cell lymphoblastic lymphoma.
|
2546634 |
1989 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of CD3 transcripts and absence of TcR gene rearrangements in prothymocytic T-ALL supports their immature T cell character.
|
3100631 |
1987 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No rearrangements of the T cell receptor beta-gene (TCR beta) and gamma-gene (TCR gamma) were found in three of four pre-T-ALL patients.
|
2822168 |
1987 |