PRDX2, peroxiredoxin 2, 7001

N. diseases: 243; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE <b>Purpose:</b> We have previously reported that PRDX2 plays an oncogenic role in colon cancer. 31388312 2019
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 Biomarker disease BEFREE <b>Purpose:</b> We have previously reported that PRDX2 plays an oncogenic role in colon cancer. 31388312 2019
CUI: C0022336
Disease: Creutzfeldt-Jakob disease
Creutzfeldt-Jakob disease 		0.100 GeneticVariation disease BEFREE Creutzfeldt-Jakob disease with a novel four extra-repeat insertional mutation in the PrP gene. 10932276 2000
CUI: C0206042
Disease: Fatal Familial Insomnia
Fatal Familial Insomnia 		0.020 GeneticVariation disease BEFREE FFI is associated with an aspartic acid to asparagine mutation at codon 178 of the PrP gene (D178N) in conjunction with methionine at the codon 129 polymorphic site on the mutant allele (cis-129M). 9270595 1997
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 Biomarker group BEFREE Ptx1 was detected in 10/14 (71.4%) of growth hormone (GH)-secreting adenomas, 12/12 (100%) of prolactin (PRL)-secreting adenomas, 18/20 (90%) of adrenocorticotropic hormone (ACTH)-secreting adenomas, 6/7 (85.7%) of thyroid-stimulating hormone (TSH)-secreting adenomas, and 17/20 (85%) of clinically non-functioning adenomas, including 9/10 (90%) of gonadotropin-subunit-positive adenomas. 11048804 2000
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE Prx II was strongly expressed in mature endothelial cells of benign vascular tumors, whereas it was expressed weakly or not expressed in immature endothelial cells in malignant tumors of Kaposi's sarcoma and angiosarcoma. 12963914 2003
CUI: C0018923
Disease: Hemangiosarcoma
Hemangiosarcoma 		0.010 AlteredExpression disease BEFREE Prx II was strongly expressed in mature endothelial cells of benign vascular tumors, whereas it was expressed weakly or not expressed in immature endothelial cells in malignant tumors of Kaposi's sarcoma and angiosarcoma. 12963914 2003
CUI: C0278592
Disease: Adult Angiosarcoma
Adult Angiosarcoma 		0.010 AlteredExpression disease BEFREE Prx II was strongly expressed in mature endothelial cells of benign vascular tumors, whereas it was expressed weakly or not expressed in immature endothelial cells in malignant tumors of Kaposi's sarcoma and angiosarcoma. 12963914 2003
CUI: C0279988
Disease: Childhood Angiosarcoma
Childhood Angiosarcoma 		0.010 AlteredExpression disease BEFREE Prx II was strongly expressed in mature endothelial cells of benign vascular tumors, whereas it was expressed weakly or not expressed in immature endothelial cells in malignant tumors of Kaposi's sarcoma and angiosarcoma. 12963914 2003
CUI: C0027668
Disease: Neoplasms, Vascular Tissue
Neoplasms, Vascular Tissue 		0.010 Biomarker group BEFREE Prx II can be used as a novel marker of endothelial cells and indicates that reactive oxygen may play a role in the pathogenesis of vascular tumors. 12963914 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.320 Biomarker disease CTD_human PRDX2 was recently reported to be a negative regulator of platelet-derived growth factor signaling, and its silencing was suggested to be involved in melanomas. 16778180 2006
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic 		0.030 Biomarker disease BEFREE Peroxiredoxin II knockout (Prdx II(-/-)) mice had a spontaneous phenotype of hemolytic anemia. 17990289 2008
CUI: C0032584
Disease: polyps
polyps 		0.010 Biomarker phenotype BEFREE TSA-like lesions in small MPs demonstrated the endoscopic finding with no or little MLH1 methylation, while the counterparts in the mixed polyps had high levels of MLH1 methylation with relatively low levels of IGFBP7 methylation. 22173745 2012
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV 		0.010 Biomarker disease BEFREE Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs. 22430214 2013
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 AlteredExpression disease BEFREE Peroxiredoxin 2 has immune regulatory functions, but its expression in human peripheral blood lymphocytes and levels in extracellular fluid in healthy subjects and rheumatoid arthritis patients are poorly described. 22565169 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.060 Biomarker disease BEFREE TSA mouse breast carcinoma cells were injected s.c. into syngeneic mice. 23048078 2012
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 Biomarker disease BEFREE TSA selectively induced uc002mbe.2 in four studied HCC cell lines. 23643933 2013
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 Biomarker disease BEFREE Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/β-catenin signaling. 24125860 2014
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 AlteredExpression disease BEFREE Peroxiredoxin 2 is upregulated in colorectal cancer and contributes to colorectal cancer cells' survival by protecting cells from oxidative stress. 24234423 2014
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.080 Biomarker disease BEFREE Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer. 25471788 2015
CUI: C0008479
Disease: Chondrosarcoma
Chondrosarcoma 		0.050 Biomarker disease BEFREE PRP-1 had strong inhibitory effect on viability of chondrosarcoma and multilineage induced multipotent adult cells (embryonic primitive cell type). 26094604 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.370 GeneticVariation disease BEFREE Prx II is FoxM1-dependently-expressed antioxidant in HCC and function as an enhancer of Ras(G12V) oncogenic potential in hepatic tumorigenesis through activation of ERK/FoxM1/cyclin D1 cascade. 26500057 2016
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 GeneticVariation phenotype BEFREE Prx II is FoxM1-dependently-expressed antioxidant in HCC and function as an enhancer of Ras(G12V) oncogenic potential in hepatic tumorigenesis through activation of ERK/FoxM1/cyclin D1 cascade. 26500057 2016
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.010 AlteredExpression group BEFREE Peroxiredoxin-2 up-regulation in inflammatory bowel disease: Friend or foe? 27869326 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer. 27894099 2016