Malignant neoplasm of breast
|
0.390 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
BEFREE |
We describe a new technique for purging breast cancer cells (BCCs) that combines two independent strategies: (a) the specific enrichment of CD34+ progenitor stem cells by magnetic antibody cell separation (MACS), and then (b) infection of the contaminating BCCs with a recombinant adGAL-TEK marker/suicide gene adenovirus (ad-v), followed by the addition of ganciclovir (GCV).
|
10389945 |
1999 |
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
BEFREE |
The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2<sup>Hi</sup> Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors.
|
28838996 |
2017 |
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
BEFREE |
Because there are only limited data on the Tie2 pathway in human breast cancer, and our previous data have suggested that breast tumors establish a blood supply by vascular remodeling, we have investigated the expression of Ang-1, Ang-2, Ang-4, and Tie2 in a series of normal and neoplastic human breast tissues.
|
11309342 |
2001 |
Malignant neoplasm of breast
|
0.390 |
Biomarker
|
disease |
BEFREE |
TEK was associated with breast cancer overall (pARTP = 0.03) and with breast cancer survival (pARTP = 0.01).
|
23832257 |
2014 |
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Comparative studies of WIBC-9, three established non-IBC xenografts, and a human breast cancer cell line (SK-BR3) by reverse transcription-PCR, ELISA, and immunohistochemistry indicated that certain human genes (interleukin 8, vascular epidermal growth factor, basic fibroblast growth factor, angiopoietin 13, Flt-1, Tie-2, and Tie-1) and certain murine genes (integrin alpha(v)beta3, flt-1, tie-2, vascular epidermal growth factor, and CD31) were overexpressed in exposure to tumor cells.
|
11212228 |
2001 |
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Prediction of metastasis risk (11 year follow-up) using VEGF-R1, VEGF-R2, Tie-2/Tek and CD105 expression in breast cancer (n=905).
|
15026804 |
2004 |
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
ANG-1, ANG-2 and VEGF levels in co-culture media and mRNA expression were upregulated and Tie2 mRNA expression was downregulated in the HUVECs and MCF-7.
|
29115538 |
2018 |
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
GTPCH/Ang-1 interaction in stromal fibroblasts and activation of Tie2 on breast tumor cells could play an important role in supporting breast cancer growth.
|
26814432 |
2016 |
Malignant neoplasm of breast
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Despite the expression of Ang1 in many human breast cancer cell lines, the gene was expressed in only three of 21 breast cancer clinical specimens, even though its receptor, Tie2, is abundant in the vasculature of all of these tumours.
|
11027428 |
2000 |