TEK, TEK receptor tyrosine kinase, 7010

N. diseases: 300; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 Biomarker disease BEFREE We considered the possibility of using TIE-2-expressing monocytes (TEMs) to predict the response in sorafenib-treated patients with advanced HCC. 28555943 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 Biomarker disease BEFREE This study aimed to assess whether measurement of peripheral plasma Dickkopf-1 (DKK1) and Tie2-expressing monocytes (TEMs) could overcome the limitations of AFP and improve the diagnostic accuracy of HCC. 28902891 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 AlteredExpression disease LHGDN Ang-2 and VEGF mRNAs in HCC were significantly higher than those in NCL tissue (P < 0.05), whereas the Ang-1 and Tie2 mRNAs showed no statistical significance (P > 0.05), though slightly lower level of Ang-1 mRNA in HCC was observed. 16830384 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 AlteredExpression disease BEFREE Ang-2 and VEGF mRNAs in HCC were significantly higher than those in NCL tissue (P < 0.05), whereas the Ang-1 and Tie2 mRNAs showed no statistical significance (P > 0.05), though slightly lower level of Ang-1 mRNA in HCC was observed. 16830384 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 Biomarker disease RGD The expressions of Ang2 and Tie2 positively correlated with microvessal density in hepatocellular carcinoma (P<0.05). 16951510 2006
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 Biomarker disease BEFREE The expression of Angiopoietin-1, Angiopoietin-2, and their receptor Tie-2 in HCC was assessed by immunohistochemistry. 15094228 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 AlteredExpression disease BEFREE The expression of the angiopoietin and Tie2 proteins was investigated in nine normal liver tissues and 52 surgically resected HCCs. 14600132 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 AlteredExpression disease BEFREE On the other hand, Ang-1 and Tie-2 mRNA expression in HCC was not different from that in adjacent liver tissue. 12717391 2003
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 AlteredExpression disease BEFREE Tie1 and Tie2 were overexpressed in large HCCs. 12017318 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.280 AlteredExpression disease BEFREE In conclusion, tumorigenicity with neovascularization was suppressed by in vivo gene transfer and sTie2 expression in a murine HCC model, suggesting a possible role for Tie2 expression in the induction of HCC neovascularization and disease progression. 11915032 2002