Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In contrast to TP1 and hTR, hTERT and telomerase activity may be of help in identifying invasive tumors and may be additional markers for classification of benign goiter and malignant thyroid carcinoma.
|
12118320 |
2002 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data show that the common expression of hTERT and HSP90 regulates telomerase activity in thyroid carcinomas.
|
14621192 |
2003 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To address this issue, several molecular markers, including human telomerase reverse transcriptase (TERT), have been tested as markers of thyroid cancer.
|
15355904 |
2004 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that loss of miR-138 expression may partially contribute to the gain of hTERT protein expression in ATC, and that further multiple miRNA targeting hTERT mRNA might be involved in the development of thyroid carcinoma.
|
18201269 |
2008 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations 1 295 228 C>T and 1 295 250 C>T (termed C228T and C250T respectively), corresponding to -124 C>T and -146 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene, have recently been reported in human cancers, but not in thyroid cancers yet.
|
23766237 |
2013 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objectives of the study were: 1) to determine the prevalence of TERT promoter mutations C228T and C250T in different thyroid cancer histological types and cell lines; and 2) to establish the possible association of TERT mutations with mutations of BRAF, RAS, or RET/PTC.
|
23833040 |
2013 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In thyroid cancers, the presence of TERT promoter mutations (when occurring together with BRAF mutations) is significantly associated with higher TERT mRNA expression, and in glioblastoma we find a trend for increased telomerase expression in cases harbouring TERT promoter mutations.
|
23887589 |
2013 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two promoter mutations, chr5:1 295 228C>T and chr5:1 295 250C>T, in the gene for telomerase reverse transcriptase (TERT) have been recently identified in thyroid cancers and shown to be important in thyroid tumor pathogenesis.
|
25121551 |
2014 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Detailed analysis of TERT across cancers shows that the strength of this association is highly variable and is strongest in copy number-stable cancers such as thyroid carcinoma.
|
25383969 |
2014 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detailed analysis of TERT across cancers shows that the strength of this association is highly variable and is strongest in copy number-stable cancers such as thyroid carcinoma.
|
25383969 |
2014 |
Thyroid carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TERT protein was found to be more expressed in neoplastic than in normal tissues, and to display a different cellular localization, suggesting that it could contribute to thyroid cancer progression by mechanisms taking place in the cytoplasm.
|
25448848 |
2015 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This suggests an important role of TERT mutational analysis in the clinical diagnosis and management of thyroid cancer patients.
|
25951319 |
2016 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, this study on a large cohort of TC patients from Middle East demonstrates that TERT promoter mutations are relatively common, especially in the non-CPTC, and are associated with more aggressive histopathological features, BRAF(V600E) mutation, and disease persistence/recurrence than the WT TERT.
|
26354077 |
2015 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A telomerase reverse transcriptase (TERT) promoter mutation was identified in thyroid cancer.
|
26727717 |
2016 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, TERT with promoter mutations represents a prominent new oncogene in thyroid cancer and the mutations are promising new diagnostic and prognostic genetic markers for thyroid cancer, which, in combination with BRAF V600E mutation or other genetic markers (e.g.
|
26733501 |
2016 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two mutations (C228T and C250T) in the promoter region of the telomerase reverse transcriptase (TERT) have recently been described in different types of cancer including follicular cell-derived thyroid cancer (TC).
|
26902827 |
2016 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent reports suggest that mutations in the promoter of the gene encoding telomerase reverse transcriptase (TERT) affect thyroid cancer outcomes.
|
26969876 |
2016 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The study explored the association between rs10069690C/T and rs2736100G/T of human telomerase reverse transcriptase (hTERT) gene, and the prognosis of thyroid cancer.
|
27472887 |
2016 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Co-regulation of TERT suggests a mechanism by which allelic variants in/near FOXE1 are associated with thyroid cancer risk.
|
27852061 |
2016 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The DNA methylation and rs2736100 polymorphisms in the promoter region of hTERT gene might be in correlation to postoperative recurrence of TC patients.
|
28587656 |
2017 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Telomerase reverse transcriptase (<i>TERT</i>) promoter mutations have been linked to adverse clinical parameters in thyroid cancer, but <i>TERT</i>-expressing tumours are not always mutated.
|
29692346 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, TERT could induce thyroid carcinoma cell proliferation mainly through the PTEN/AKT signaling pathway.
|
29901196 |
2018 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Telomerase reverse transcriptase (TERT) promoter mutations have been described in different pathological types of thyroid cancers (TC).
|
30024548 |
2018 |
Thyroid carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Telomerase reverse transcriptase (TERT) promoter mutations have recently been identified as an important prognostic factor in thyroid cancer.
|
30102829 |
2018 |
Thyroid carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the association between TERT promoter mutations and recurrence in a prospective series of 173 intermediate- to high-risk patients with thyroid cancer.
|
30648628 |
2019 |