TFAP2C, transcription factor AP-2 gamma, 7022

N. diseases: 51; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.030 AlteredExpression phenotype BEFREE Our findings suggest PPARɣ inactivation, as well as TFAP2A and TFAP2C overexpression cooperate with other TFs to promote the basal-squamous transition during tumor progression. 31772149 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.030 Biomarker phenotype BEFREE This study shows that TFAP2C promoted tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling. 27885255 2016
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.030 Biomarker phenotype BEFREE The roles of TFAP2C in mammary gland tumorigenesis and in pathways critical to cancer progression remain poorly understood. 25772240 2015