|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
(3) These results further support the concept that the overexpression of TFE3 or TFEB in these neoplasms activates the expression of genes normally regulated by microphthalmia transcription factor in other cell types.
|
19396149 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
(4) One patients with a TFE3+ and MITF+ tumor and 66-87,XXY,der(1)t(1;8)del(4)(q?) der(11)t(11;15)der17t(X;17 abnormalities died 9 months after diagnosis.
|
16880148 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TFE3 and Cathepsin K remain the most sensitive and specific markers of these neoplasms.
|
20679884 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
TFE3 translocation-associated perivascular epithelioid cell neoplasm (PEComa) of the gynecologic tract: morphology, immunophenotype, differential diagnosis.
|
25517951 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TFE3-Expressing Perivascular Epithelioid Cell Neoplasm (PEComa) of the Sella Turcica.
|
27189222 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TFE3 regulates both Golgi and lysosomal homeostasis and is rearranged in renal cell carcinoma (RCC), alveolar soft part sarcoma, epithelioid hemangioendothelioma, and perivascular epitheloid cell tumors (PEComas).
|
31774608 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All tumors showed strong nuclear immunopositivity for TFE3.
|
30920708 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As a result, 5 tumors showed a positive reaction for TFE3 with a range from 1+ to 2+ in intensity.No tumors were positive for TFEB.
|
21424937 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As the true frequency of these neoplasms as well as the biological properties of TFE3 activation in renal cell carcinomas are largely unknown, we have examined TFE3 expression as well as the underlying genetic alterations in a large, hospital-based series of renal cell carcinomas with long-term follow-up information.
|
22037260 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both the primary tumor and the JU-PI cells showed nuclear expression of the TFE3 transcription factor but TFE3-activating chromosomal rearrangements were not found.
|
29788803 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Both Xp11 translocation renal cell carcinomas and the corresponding mesenchymal neoplasms are characterized by a variety of gene fusions involving TFE3.
|
29713041 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By immunohistochemistry, the tumor was positive for TFE3; HMB-45 stained approximately 5% of tumor cells corresponding to the histologic melanin pigment, which was confirmed with Fontana-Masson stain with bleach.
|
28877054 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Combined RNA sequencing and fluorescence in situ hybridization analysis identified 9 (23%) TFE3 gene-rearranged tumors, with 3 cases showing an SFPQ/PSF-TFE3 fusion and 1 case showing a novel DVL2-TFE3 gene fusion.
|
25651471 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Diagnostic tools to detect translocations involving the TFE3 gene on chromosome X would be valuable in the evaluation of these tumors.
|
20421778 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Fluorescence in situ hybridization results showed the presence of TFE3 gene rearrangement in all four tumors, and molecular analysis revealed SDHB mutations in neoplastic cells of three tumors.
|
27910947 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Four genes in our study were CMRI-H and could thus possibly play a role in the development of MSI-H tumors: TFE3 (9/38), TEF4 (12/38), RGS12 (11/38), and TCF1 (12/38).
|
12461749 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, proposed criteria do not apply to other clinical presentations and have not been assessed in the YAP1-TFE3 positive tumors.
|
31537895 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the tumor demonstrated moderately (2+) or strongly (3+) positive staining for TFEB, Cathepsin K, Ksp-cadherin, and vimentin but negative for TFE3, CD10, HMB45, melan A, CKpan, and CK7.
|
23826432 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, this tumour showed negative results in TFE3 and TFEB immunochemistry and split fluorescence in-situ hybridisation (FISH) assays.
|
29148086 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Identification of molecular tumor markers in renal cell carcinomas with TFE3 protein expression by RNA sequencing.
|
24339735 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
If reproducible using immunohistochemistry (IHC), this finding would have important implications for pathologists in the diagnosis of Xp11.2 RCC, calling into question the specificity of nuclear immunoreactivity for TFE3 in these tumors.
|
23628822 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IHC showed that tumor cells were diffusely positive for TFE3 and exhibited patchy and weak HMB45 staining.
|
30103811 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical evaluation on the biopsy reveals that the tumor is positive for PAX-8, CD10, and TFE3.
|
28877071 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical evaluation revealed that the tumor cells showed nuclear labeling for TFE3 protein.
|
19298350 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical stains performed on the nephrectomy specimen showed tumor positivity for CD10, E-cadherin, a-methylacyl coenzyme A racemase, and TFE3 supporting the diagnosis of Xp11 translocation renal cell carcinoma.
|
28185421 |
2017 |