|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here, we describe a case of TFE3 translocation associated RCC in a 58-year-old patient, with emphasis on cytomorphologic features and clues toward this diagnostic entity.
|
29024535 |
2018 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Notably, 7/9 (78%) renal cell carcinomas exhibiting subnuclear clearing and linear nuclear array (6 of which showed high World Health Organization/International Society of Urological Pathology nucleolar grade) demonstrated TFE3 translocation, an association that was statistically significant when compared with renal cell carcinomas without MITF aberrations (P=0.009).
|
28840857 |
2018 |
|
Renal Cell Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas.
|
30849994 |
2019 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Finally, pathologists should recognize that the histology of RCC associated with Xp11.2 translocation/TFE3 gene fusion may focally resemble that of chromophobe RCC, but TFE3 immunohistochemistry and molecular genetic study may be helpful in the differential diagnosis.
|
20683695 |
2010 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cytogenetic analysis revealed a karyotype of t(X;1)(p11.2; p34.3), consistent with a TFE3-associated RCC.
|
15383938 |
2005 |
|
Renal Cell Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We selected 54 patients with renal cell carcinoma with positive nuclear transcription factor E3 and transcription factor EB expression from the Juvenile RCC Network.
|
21074195 |
2011 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest that renal cell carcinomas (RCCs) associated with the newly recognized Xp11.2 translocation (transcription factor E3 [TFE3] gene fusions) can be found among adults with RCC showing a very aggressive disease-course.
|
21070573 |
2011 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To broaden the spectrum of Xp11 neoplasms, we investigated a novel tumor exhibiting morphologies overlapping Xp11.2 translocation/TFE3 rearrangement-associated RCC and the mesenchymal counterpart with melanocytic differentiation by immunohistochemistry, fluorescence in situ hybridization (FISH) and RNA sequencing, as well as literature review.
|
31277953 |
2019 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previously, we demonstrated that in t(X;1)(p11;q21)-positive renal cell carcinomas (RCCs), the TFE3 gene on the X chromosome is disrupted and fused to the PRCC gene on chromosome 1.
|
12837690 |
2003 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we describe a case of TFE3-positive RCC in which metastatic relapse to the mediastinal lymph nodes and pulmonary nodules was treated with single-agent sunitinib, a multitargeted tyrosine inhibitor.
|
22995920 |
2013 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Renal cell carcinomas (RCCs) with Xp11 translocation (Xp11 RCC) constitute a distinctive molecular subtype characterized by chromosomal translocations involving the Xp11.2 locus, resulting in gene fusions between the TFE3 transcription factor with a second gene (usually ASPSCR1, PRCC, NONO, or SFPQ).
|
28411178 |
2017 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These cases validate RBM10-TFE3 as a recurrent gene fusion in Xp11 translocation RCC, illustrate a source of false-negative TFE3 break-apart FISH, and highlight the complementary role of TFE3 IHC and TFE3 FISH.
|
28296677 |
2017 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, a unique translocation between the X chromosome and chromosome 1 or t(X;1) has been described in several reports of renal cell carcinomas (RCCs) diagnosed in children and adolescents that results in PRCC-TFE3 gene fusion.
|
16807766 |
2006 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our study confirms that TFE3-positive RCC exhibits a deregulation of the cell cycle apparently unrelated to the young age of the patients.
|
19246164 |
2009 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Moreover, MITF and TFE3 reciprocally rescue one another in lines derived from CCS or pediatric renal carcinoma.
|
16766266 |
2006 |
|
Renal Cell Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Identification of molecular tumor markers in renal cell carcinomas with TFE3 protein expression by RNA sequencing.
|
24339735 |
2013 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although rare, RBM10-TFE3 fusion variant (from chromosome X paracentric inversion), therefore, appears to be a recurrent molecular event in Xp11.2 RCCs.
|
26998913 |
2016 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The papillary renal cell carcinoma (RCC)-associated (X;1)(p11;q21) translocation fuses the genes PRCC and TFE3 and leads to cancer by an unknown molecular mechanism.
|
11717438 |
2001 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Among the 27 renal cell carcinomas with TFE3 strong positive immunostaining, 20 cases were diagnosed as Xp11 translocation renal cell carcinoma, and seven cases were diagnosed as clear cell renal cell carcinoma.
|
31175325 |
2019 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This is the first time to correlate the MED15-TFE3 renal cell carcinoma with specific clinicopathologic features.
|
29713041 |
2018 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Translocation renal cell carcinoma: lack of negative impact due to lymph node spread.
|
18278810 |
2008 |
|
Renal Cell Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Establishment and characterization of a renal cell carcinoma cell line (FU-UR-1) with the reciprocal ASPL-TFE3 fusion transcript.
|
15138551 |
2004 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Oncogenic TFE3 fusion proteins define a subset of pediatric renal adenocarcinomas and one fusion (ASPL-TFE3) is also characteristic of alveolar soft part sarcoma (ASPS).
|
17283122 |
2007 |
|
Renal Cell Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Magnetic resonance imaging and computed tomography characteristics of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion.
|
24926688 |
2014 |
|
Renal Cell Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We screened 983 RCC specimens.TFE3 immunohistochemical staining and FISH assay confirmed 22 Xp11.2 RCCs out of 65 suspicious cases.
|
26169997 |
2015 |