|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TFE3 regulates both Golgi and lysosomal homeostasis and is rearranged in renal cell carcinoma (RCC), alveolar soft part sarcoma, epithelioid hemangioendothelioma, and perivascular epitheloid cell tumors (PEComas).
|
31774608 |
2020 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transcription factor E3 (TFE3) is a useful marker for tumors with Xp11.2 translocation, including alveolar soft part sarcoma and renal cell carcinoma.
|
31788112 |
2019 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We here report an interesting and challenging case of malignant PEComa that showed transcription factor E3 (TFE3) protein expression and rearrangement, paucity of muscle and melanocytic marker expression, and morphologically mimicked alveolar soft part sarcoma.
|
29208563 |
2018 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activity and safety of crizotinib in patients with alveolar soft part sarcoma with rearrangement of TFE3: European Organization for Research and Treatment of Cancer (EORTC) phase II trial 90101 'CREATE'.
|
29216400 |
2018 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, among neoplasms with the SFPQ-TFE3, NONO-TFE3, DVL2-TFE3, and ASPL-TFE3 gene fusions, the RCCs are almost always PAX8 positive, cathepsin K negative by immunohistochemistry, whereas the mesenchymal counterparts (Xp11 translocation PEComas, melanotic Xp11 translocation renal cancers, and alveolar soft part sarcoma) are PAX8 negative, cathepsin K positive.
|
26975036 |
2016 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Validation and utilization of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinoma and alveolar soft part sarcoma.
|
26415891 |
2015 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is characterized by a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in fusion of the transcription factor E3 (TFE3) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.
|
26516944 |
2015 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Alveolar soft part sarcoma of lung: report of a unique case with emphasis on diagnostic utility of molecular genetic analysis for TFE3 gene rearrangement and immunohistochemistry for TFE3 antigen expression.
|
26369552 |
2015 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The current report describes a unique case of vulvovaginal alveolar soft part sarcoma showing the classic morphologic features with documentation of TFE3 protein expression and the ASPL-TFE3 gene rearrangement.
|
24681737 |
2014 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: validation and clinical experience with 75 cases.
|
23828314 |
2014 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ultrastructurally, the ASPL-TFE3 RCC variant contains rhomboid crystals in the cytoplasm, similar to that observed in alveolar soft part sarcoma.
|
22207547 |
2012 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that the most sensitive marker of alveolar soft part sarcoma was the presence of the ASPSCR1-TFE3 fusion transcript.
|
21835426 |
2012 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All conventional sections from the Xp11.2 RCC and alveolar soft part sarcoma cases were positive for the TFE3 rearrangement by FISH.All remaining cases were negative.
|
21817901 |
2011 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include a distinctive RCC that bears a translocation with the identical chromosomal breakpoints (Xp11.2, 17q25) and identical resulting ASPL-TFE3 gene fusion as alveolar soft part sarcoma.
|
20073616 |
2010 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The resulting gene fusions involve the TFE3 transcription factor gene and multiple reported genes, including the same one (ASPL) found in the characteristic gene fusion of alveolar soft part sarcoma.
|
20438411 |
2010 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma.
|
18176180 |
2008 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Renal carcinomas associated with Xp11.2 translocations that result in fusions involving the TFE3 transcription factor gene have been delineated, including a distinctive neoplasm that shares the identical gene fusion as alveolar soft part sarcoma.
|
12973047 |
2003 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thirty-nine of 40 neoplasms characterized by TFE3 gene fusions (19 of 19 alveolar soft part sarcoma, 20 of 21 renal carcinomas) demonstrated moderate or strong nuclear TFE3 immunoreactivity.
|
12766578 |
2003 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents.
|
11438465 |
2001 |
|
Adult Alveolar Soft Part Sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25.
|
11244503 |
2001 |