|
Refractory Cytopenia of Childhood
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The diagnosis was TFE3/Xp11.2 translocation RCC.
|
28478739 |
2019 |
|
Refractory Cytopenia of Childhood
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report a case of a 44-year-old man who has been treated with everolimus for a Xp11.2 translocation/TFE3 gene-fusion RCC after 2 previous failed treatments with tyrosine kinase inhibitor.
|
29702156 |
2018 |
|
Refractory Cytopenia of Childhood
|
0.100 |
Biomarker
|
disease |
BEFREE |
These cases validate RBM10-TFE3 as a recurrent gene fusion in Xp11 translocation RCC, illustrate a source of false-negative TFE3 break-apart FISH, and highlight the complementary role of TFE3 IHC and TFE3 FISH.
|
28296677 |
2017 |
|
Refractory Cytopenia of Childhood
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Herein, we examined 5 additional cases of SFPQ-TFE3 RCCs using clinicopathologic, immunohistochemical, and molecular analyses.
|
28315422 |
2017 |
|
Refractory Cytopenia of Childhood
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the frequency of translocation renal cell carcinoma (RCC) by reverse transcription polymerase chain reaction (RT-PCR) and how well the TFE3 immunoreactivity is concordant with TFE3 gene translocation status proved by fluorescence in situ hybridization (FISH) assay and RT-PCR.
|
28415646 |
2017 |
|
Refractory Cytopenia of Childhood
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similar subnuclear vacuolization was also characteristic of SFPQ-TFE3 RCC, creating overlapping features with clear cell papillary RCC.
|
26975036 |
2016 |
|
Refractory Cytopenia of Childhood
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Regarding translocation renal cell carcinoma (RCC), TFE3, TFEB and ALK protein expression is crucial in establishing the diagnosis of Xp11.2 RCC, renal carcinoma with t(6;11)(p21;q12), and renal carcinoma with ALK rearrangement, respectively.
|
23957913 |
2013 |
|
Refractory Cytopenia of Childhood
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the clinical and pathologic features and the prognostic relevance of unclassified RCC with -TFE3 over-expression in our adult series.
|
21070573 |
2011 |
|
Refractory Cytopenia of Childhood
|
0.100 |
Biomarker
|
disease |
BEFREE |
We immunohistochemically analyzed TFE3 nuclear expression in 809 cases of RCCs using 14 tissue microarray blocks and selected nine cases those showed moderate to strong positive nuclear immunoreactivity for TFE3.
|
21773754 |
2011 |
|
Refractory Cytopenia of Childhood
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with Xp11 translocation/TFE3 fusion gene metastatic RCC who had received targeted therapy were identified.
|
20154303 |
2010 |
|
Refractory Cytopenia of Childhood
|
0.100 |
Biomarker
|
disease |
BEFREE |
A retrospective review was conducted to describe the clinical characteristics and outcome of adult patients with metastatic Xp11.2 RCC who had strong TFE3 nuclear immunostaining and received anti-VEGF therapy.
|
20665500 |
2010 |
|
Refractory Cytopenia of Childhood
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We created 2 tissue microarrays (TMA) containing five 1.4-mm cores from each of 21 Xp11 translocation RCC (all confirmed by TFE3 IHC, 6 further confirmed by genetics), 7 clear cell RCC (CCRCC), and 6 papillary RCC (PRCC).
|
20679884 |
2010 |
|
Refractory Cytopenia of Childhood
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pediatric renal cell carcinoma (RCC) associated with ASPL-TFE3 gene fusion resulting from balanced translocation, t(X;17)(p11.2;q25), is a distinctive tumor entity.
|
17149613 |
2007 |
|
Refractory Cytopenia of Childhood
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The papillary renal cell carcinoma (RCC)-associated (X;1)(p11;q21) translocation fuses the genes PRCC and TFE3 and leads to cancer by an unknown molecular mechanism.
|
11717438 |
2001 |