|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We found an inverse correlation of TFR-1 and TFR-2 expression in AFP and tumour differentiation.
|
30811632 |
2019 |
|
Aplastic Anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There were marked abnormalities in iron regulation gene expression between the AA and composite model groups, as seen by the significant decrease of hepcidin expression in the liver (P<0.01) that paralleled the changes in BMP6, SMAD4, and TfR2.
|
29434729 |
2018 |
|
Arthralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
TFR2-related haemochromatosis in the Netherlands: a cause of arthralgia in young adulthood.
|
28276324 |
2017 |
|
Iron-Refractory Iron Deficiency Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we analyze multiple murine genetic models of iron dysregulation, including β-thalassemia intermedia (Hbb(th3/+)), hereditary hemochromatosis (Hfe(-/-), Hjv(-/-), and Tfr2(Y245X/Y245X)), hypotransferrinemia (Trf(hpx/hpx)), heterozygous transferrin receptor 1 deficiency (Tfrc(+/-)) and iron refractory iron deficiency anemia (Tmprss6(-/-) and Tmprss6(hem8/hem8)).
|
25425686 |
2015 |
|
Beta thalassemia intermedia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we analyze multiple murine genetic models of iron dysregulation, including β-thalassemia intermedia (Hbb(th3/+)), hereditary hemochromatosis (Hfe(-/-), Hjv(-/-), and Tfr2(Y245X/Y245X)), hypotransferrinemia (Trf(hpx/hpx)), heterozygous transferrin receptor 1 deficiency (Tfrc(+/-)) and iron refractory iron deficiency anemia (Tmprss6(-/-) and Tmprss6(hem8/hem8)).
|
25425686 |
2015 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In GBM, a highly significant correlation (p<0.0001) was found between the expression level of TfR2 and overall survival, showing that higher levels of TfR2 expression were associated with an overall longer survival.
|
25891893 |
2015 |
|
Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transferrin (P < 0.01) and transferrin receptor 2 (P < 0.01) mRNA were elevated in NASH patients.
|
25000850 |
2015 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Type 2 transferrin receptor (TFR2) participates in cellular iron overload and is related to cardiovascular disease.
|
23751596 |
2014 |
|
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variations in TFR2 gene and coronary heart disease in Chinese: a case-control study.
|
23751596 |
2014 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We did not find significant associations between variants of TFR2 gene (including tagSNPs rs2075674 and rs7385804) and the risk of CHD.
|
23751596 |
2014 |
|
Glycogen storage disease type II
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Variability of the transferrin receptor 2 gene in AMD.
|
24648608 |
2014 |
|
Fibrosis, Liver
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic loci associated with iron metabolism (TF, TMPRSS6, PCSK7, TFR2 and Chr2p14) in recent GWAS and liver fibrosis (PNPLA3) in recent meta-analysis were analyzed for association with either liver cirrhosis or advanced fibrosis in 148 German HFE C282Y homozygotes.
|
24556216 |
2014 |
|
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variations in TFR2 gene and coronary heart disease in Chinese: a case-control study.
|
23751596 |
2014 |
|
Iron deficiency anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that TF, TFR2 and TMPRSS6 polymorphisms are significantly associated with decreased iron status, but only variants in TMPRSS6 are genetic risk factors for iron deficiency and IDA.
|
22323359 |
2012 |
|
Metabolic Syndrome X
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Four patients were double heterozygous or compound heterozygous for the mutations mentioned above, and the patient with metabolic syndrome was heterozygous for a mutation in the TFR2 gene.
|
22890139 |
2012 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the mRNA levels of hepcidin (HAMP), HFE, neogenin (NEO1), transferrin receptor 1 (TFRC), transferrin receptor 2 (TFR2), and hemojuvelin (HFE2) in normal human brain, brain tumors, and astrocytoma cell lines.
|
19386095 |
2009 |
|
Childhood Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the mRNA levels of hepcidin (HAMP), HFE, neogenin (NEO1), transferrin receptor 1 (TFRC), transferrin receptor 2 (TFR2), and hemojuvelin (HFE2) in normal human brain, brain tumors, and astrocytoma cell lines.
|
19386095 |
2009 |
|
Hepatitis C
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes.
|
18565178 |
2008 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results allude to differential regulation of TfR1 and TfR2 expression in normal B cells vs. CLL.
|
18621559 |
2008 |
|
Porphyria Cutanea Tarda
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes.
|
18565178 |
2008 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These observations suggest that TfR2 expression may be altered in human cancers and warrant further studies in primary tumors.
|
17428703 |
2007 |
|
beta^+^ Thalassemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found decreased expression of hepcidin and TfR2 and increased expression of TfR1 and NGAL in the beta-thalassemia mouse models, compared with the control mice.
|
16755567 |
2006 |
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We studied the prevalence of 12 hereditary hemochromatosis (HH) gene mutations (C282Y, V53M, V59M, H63D, H63H, S56C, Q127H, E168Q, E168X, W169X and Q283P in the HFE gene and Y250X in the TFR2 gene) and its correlation with the iron status in 82 adult patients with acute leukemia (AL); 48 patients (58.5%) were affected by acute myeloid leukemia (AML) and 34 patients (41.5%) by acute lymphoblastic leukemia (ALL); 27 patients (32.9%) had at least one HH gene mutation (6 heterozygous for C282Y, 6 homozygous for H63D, 13 heterozygous for H63D and 2 heterozygous for S56C).
|
15863206 |
2005 |