TFRC, transferrin receptor, 7037

N. diseases: 359; N. variants: 40
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.330 AlteredExpression disease BEFREE These results allude to differential regulation of TfR1 and TfR2 expression in normal B cells vs. CLL. 18621559 2008
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.330 AlteredExpression disease BEFREE Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia. 16054692 2006
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.330 AlteredExpression disease BEFREE Based on this, we propose that one molecular mechanism by which 11q23 deletions confer a poor prognosis in CLL is via increased TfR expression secondary to ATM loss, resulting in the increased cellular iron import, and hence increased capacity for malignant growth. 16326028 2006
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia
0.330 Biomarker disease CTD_human The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. 16904380 2006