|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
High expression of TFR-1 in HCC was associated with the absence of alcohol abuse (P = 0.0467), liver cirrhosis (P < 0.0001), higher alpha-fetoprotein (AFP; P < 0.0001), smaller tumour size (P = 0.0022), poor histological differentiation (P < 0.0001) and morphological features (P < 0.0001).
|
30811632 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here we show that in hepatocellular carcinoma (HCC) TFR1 expression is regulated by miR-148a.
|
30728365 |
2019 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overall, these results reveal that TfR-BiTE can selectively deplete TfR-positive HepG2 cells; hence, it represents a novel immunotherapeutic approach for the treatment of hepatocellular carcinoma.
|
31293575 |
2019 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
A stabilized retro-inverso peptide ligand of transferrin receptor for enhanced liposome-based hepatocellular carcinoma-targeted drug delivery.
|
30395963 |
2019 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma.
|
30076742 |
2018 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Over-expression of transferrin receptor 1 (TFRC) is observed in hepatocellular carcinoma (HCC); however, there is a lack of conclusive information regarding the mechanisms of this dysregulation.
|
26657500 |
2016 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin, ceruloplasmin, transferrin, and transferrin receptor 2 were downregulated, while transferrin receptor 1 was upregulated in HCC.
|
19387685 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this study, transferrin receptor expression in normal human hepatocyte and two hepatocellular-carcinoma cells (Huh7/SK-Hep1) was determined. p53-LipofectAMINE with different amounts of transferrin was transfected into the cells and the gene transfection efficiency was evaluated.
|
18347429 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
RGD |
Expression of iron regulatory genes in a rat model of hepatocellular carcinoma.
|
16953838 |
2006 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The effects of cellular proliferation on the uptake of transferrin-bound iron (Tf-Fe) and expression of transferrin receptor-1 (TfR1) and transferrin receptor-2 (TfR2) were investigated using a human hepatoma (HuH7) cell line stably transfected with TfR1 antisense RNA expression vector to suppress TfR1 expression.
|
14512884 |
2003 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In contrast, transferrin receptor (TfR) was shown to be overexpressed in the same HCC samples.
|
12029631 |
2002 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Together with other cancer associated auto-antibodies such as anti-p53, anti-p62, anti-Koc, and anti-CENP-F, auto-antibodies to p90 represent a new marker for tumors such as HCC and gastric cancer.
|
12118381 |
2002 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Individuals carrying the HFE282Tyr allele (homo- and heterozygotes) in combination with homozygosity for the TFR Ser allele showed an increased risk for HCC (OR = 3.5; 95% confidence interval, CI = 1.3-9.3), which was further increased in HFE Tyr homozygotes and compound (Tyr/Asp) heterozygotes in combination with TFR 142Ser homozygosity (OR = 17.2; 95% CI = 1.8-168.9).
|
11096344 |
2000 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Antisense suppression of transferrin receptor gene expression in a human hepatoma cell (HuH-7) line.
|
8380064 |
1993 |