TGFA, transforming growth factor alpha, 7039

N. diseases: 376; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030354
Disease: Papilloma
Papilloma
0.320 AlteredExpression disease BEFREE Previously, after 7 mo TPA promotion of HK1.TGFalpha mice that express moderate levels of TGFalpha elicited papillomas that remained regression-prone and benign for up to 2 yr. 10569807 1999
CUI: C0030354
Disease: Papilloma
Papilloma
0.320 Biomarker disease CTD_human Analysis of EGFR, TGF-alpha, neu and c-myc in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mammary tumors using RT-PCR. 8603490 1995
CUI: C0030354
Disease: Papilloma
Papilloma
0.320 Biomarker disease BEFREE These unusual regional and developmental effects of TGF-alpha suggest a natural role for the growth factor in (1) controlling epidermal thickness during development and differentiation, (2) involvement in papilloma formation, presumably in conjunction with TGF-beta, and (3) involvement in psoriasis, in conjunction with some as yet unidentified secondary stimulus stemming from mild mechanical irritation/bacterial infection. 1709129 1991