TGFB1, transforming growth factor beta 1, 7040

N. diseases: 1558; N. variants: 50
Disease: Pulmonary Fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease HPO
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 AlteredExpression disease BEFREE Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. 1862087 1991
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE Transforming growth factor beta 1 (TGF-beta 1) is thought to be the mediator of fibrosis in liver, glomerular, and pulmonary fibrosis. 7768393 1995
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE These histopathologic changes induced by the transforming growth factor beta 1 and platelet-derived growth factor B gene are partly akin to those changes seen in lung tissues from patients with pulmonary fibrosis and markedly contrast with the changes induced by overexpression of the IL-6 and IL-6 receptor genes that mimics lymphocytic interstitial pneumonia. 7568174 1995
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE The production of TGF-beta1 is under genetic control, and this in turn influences the development of lung fibrosis. 9808485 1998
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE We conclude that a decreased capacity to up-regulate COX-2 expression and COX-2-derived PGE(2) synthesis in the presence of increasing levels of profibrotic mediators such as TGF-beta(1) may lead to unopposed fibroblast proliferation and collagen synthesis and contribute to the pathogenesis of pulmonary fibrosis. 11290559 2001
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 AlteredExpression disease BEFREE The results indicate a role for induction of c-jun and TGF-beta 1 expression in the development of AM-induced pulmonary fibrosis in the Fischer 344 rat and provide potential targets for therapeutic intervention. 11597910 2001
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 AlteredExpression disease BEFREE Two anti-inflammatory cytokines, interleukin-1 receptor antagonist and transforming growth factor-beta1, had increased expression, consistent with other human fibrotic lung diseases and animal models of lung fibrosis. 11970906 2002
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE These findings suggest that the differences in susceptibility to pulmonary fibrosis are downstream from TGF-beta1 and that fibrosis-prone individuals may have an altered collagen metabolism in the lungs that is balanced toward a "nondegrading" environment. 12151305 2002
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 AlteredExpression disease BEFREE Early elevated cutaneous mRNA expression of TGF-beta1, but not TGF-beta2 or TGF-beta3, and elevated C-C chemokines macrophage chemoattractant protein-1, macrophage inflammatory protein-1alpha, and RANTES precede subsequent skin and lung fibrosis. 11884483 2002
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 GeneticVariation disease BEFREE Our results indicate that the homozygous wild type of the G915C single nucleotide polymorphism in the coding region of the TGF-beta1 gene, which was recently associated with elevated TGF-beta1 production and pulmonary fibrosis, may influence the predisposition to Peyronie's disease. 12478192 2003
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 GeneticVariation disease BEFREE Our results suggest that TGFbeta1 polymorphisms do not play a role in the pathogenesis of SSc, even though there remains the possibility of a risk factor for genetic susceptibility to pulmonary fibrosis. 12858451 2003
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease CTD_human Fibrogenic cytokine levels in bronchoalveolar lavage aspirates 15 years after exposure to sulfur mustard. 15286001 2004
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease LHGDN Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. 15133032 2004
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease CTD_human Abnormal expression of TGF-beta1 is believed to play an important role in the pathogenesis of a number of chronic inflammatory and immune lung diseases, including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. 16365456 2006
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease CTD_human Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. 16324872 2006
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE Transforming Growth Factor beta 1(TGF-beta1) is a key effector cytokine in the development of lung fibrosis. 16948840 2006
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE In addition, profibrotic transforming growth factor-beta1 (TGF-beta1) was decreased in hHGF-treated lungs, indicating an involvement of TGF-beta1 in hHGF-induced reduction of lung fibrosis. 17056705 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE We have recently reported that IL-6 and TGF-beta(1) plays an important role in proliferation and differentiation of lung fibroblasts, and all-trans-retinoic acid (ATRA) prevented bleomycin-induced lung fibrosis through the inhibition of these cytokines. 17579094 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease CTD_human Levels of cytokine in bronchoalveolar lavage (BAL) fluid in patients with pulmonary fibrosis due to sulfur mustard gas inhalation. 17266442 2007
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE Because the transcriptional response of fibroblasts to transforming growth factor-beta(1) (TGF-beta(1)) is a determinant of disease progression, we investigated the role of the transcriptional regulator inhibitor of differentiation-1 (Id1) in the setting of lung fibrosis. 18583319 2008
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 AlteredExpression disease BEFREE Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. 18188456 2008
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis. 18403781 2008
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 AlteredExpression disease BEFREE TGF-beta1-induced upregulation of arginase-1 suggests an interplay between profibrotic agents and l-arginine metabolism during the course of lung fibrosis in the mouse, whereas species-specific regulatory mechanisms may account for the differences observed in mouse and human. 17934065 2008
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.700 Biomarker disease BEFREE Mediators of preferably mesenchymal repair such as transforming growth factor beta(1) (TGF-beta(1)) and mediators of polarized cellular immunity such as interleukin (IL)-13 are thought to be of key importance for progression of lung fibrosis. 18525195 2008