TGFB1, transforming growth factor beta 1, 7040

N. diseases: 179; N. variants: 27
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011989
Disease: Camurati-Engelmann Syndrome
Camurati-Engelmann Syndrome 		0.800 Biomarker disease CTD_human
CUI: C0011989
Disease: Camurati-Engelmann Syndrome
Camurati-Engelmann Syndrome 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C0011989
Disease: Camurati-Engelmann Syndrome
Camurati-Engelmann Syndrome 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.700 Biomarker disease CTD_human
CUI: C0392164
Disease: Pulmonary Cystic Fibrosis
Pulmonary Cystic Fibrosis 		0.310 Biomarker disease CTD_human
CUI: C1527396
Disease: Fibrocystic Disease of Pancreas
Fibrocystic Disease of Pancreas 		0.300 Biomarker disease CTD_human
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.350 Biomarker group CTD_human Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats. 1281619 1992
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.350 Biomarker group CTD_human Nephrotic syndrome induced by puromycin aminonucleoside (PAN) is characterized by tubulointerstitial (TI) inflammation, foci of TI fibrosis, and increased renal mRNA levels for matrix genes, the tissue inhibitor of metalloproteinases (TIMP), and the transforming growth factor-beta 1 (TGF-beta 1). 8023968 1994
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.310 Biomarker disease CTD_human Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis. 8148055 1994
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.310 Biomarker group CTD_human Altered expression of transforming growth factor-beta 1 mRNA and protein in mouse skin carcinogenesis. 8148055 1994
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Biomarker disease CTD_human Molecular biological analyses of the induced lesions revealed point mutations in the p53 gene in 60.9% of HCCs, and elevated expression of mRNAs for p53, c-myc, c-fos, TGF-alpha, TGF-beta1, alpha-fetoprotein, GST-P, and GGT, and decreased mRNA expression of EGF and EGFR in HCCs when compared to controls. 9029167 1997
CUI: C0016059
Disease: Fibrosis
Fibrosis 		0.600 Biomarker phenotype CTD_human In conclusion, this strongly suggests that TGF-beta1 derived from tubular epithelial cells and some macrophages might be related to the development of renal interstitial fibrosis in HgCl2-treated BN rats. 10469268 1999
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.400 Biomarker disease CTD_human Kinetics of transforming growth factor-beta1 and extracellular matrix in renal tubulointerstitial lesions of mercuric chloride-treated Brown Norway rats. 10469268 1999
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.350 Biomarker group CTD_human Renal protective effects of blocking the intrarenal renin-angiotensin system. 10515446 1999
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.330 Biomarker disease CTD_human Kinetics of transforming growth factor-beta1 and extracellular matrix in renal tubulointerstitial lesions of mercuric chloride-treated Brown Norway rats. 10469268 1999
CUI: C1565662
Disease: Acute Kidney Insufficiency
Acute Kidney Insufficiency 		0.300 Biomarker disease CTD_human Kinetics of transforming growth factor-beta1 and extracellular matrix in renal tubulointerstitial lesions of mercuric chloride-treated Brown Norway rats. 10469268 1999
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.300 Biomarker disease CTD_human Kinetics of transforming growth factor-beta1 and extracellular matrix in renal tubulointerstitial lesions of mercuric chloride-treated Brown Norway rats. 10469268 1999
CUI: C0011989
Disease: Camurati-Engelmann Syndrome
Camurati-Engelmann Syndrome 		0.800 Biomarker disease GENOMICS_ENGLAND Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease. 11062463 2000
CUI: C0011989
Disease: Camurati-Engelmann Syndrome
Camurati-Engelmann Syndrome 		0.800 GeneticVariation disease UNIPROT Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. 10973241 2000
CUI: C0011989
Disease: Camurati-Engelmann Syndrome
Camurati-Engelmann Syndrome 		0.800 GeneticVariation disease UNIPROT Mutations in the gene encoding the latency-associated peptide of TGF-beta 1 cause Camurati-Engelmann disease. 11062463 2000
CUI: C0019284
Disease: Diaphragmatic Hernia
Diaphragmatic Hernia 		0.500 Biomarker phenotype CTD_human Administration of antenatal glucocorticoids upregulates peptide growth factor gene expression in nitrofen-induced congenital diaphragmatic hernia in rats. 10646786 2000
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.400 Therapeutic disease CTD_human Enhanced tumorigenesis and reduced transforming growth factor-beta type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-beta1. 11074608 2000
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.400 Biomarker disease CTD_human Enhanced tumorigenesis and reduced transforming growth factor-beta type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-beta1. 11074608 2000
CUI: C0029458
Disease: Osteoporosis, Postmenopausal
Osteoporosis, Postmenopausal 		0.390 Biomarker disease CTD_human Association of transforming growth factor beta1 genotype with therapeutic response to active vitamin D for postmenopausal osteoporosis. 10750555 2000