TGFB1, transforming growth factor beta 1, 7040

N. diseases: 1558; N. variants: 50
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4551596
Disease: Abnormal renal morphology
Abnormal renal morphology
0.010 Biomarker disease BEFREE Potential biological role of transforming growth factor-beta1 in human congenital kidney malformations. 11073823 2000
Abnormal subcutaneous fat tissue distribution
0.100 Biomarker phenotype HPO
Abnormality of pelvic girdle bone morphology
0.100 Biomarker disease HPO
CUI: C4021742
Disease: Abnormality of the humerus
Abnormality of the humerus
0.100 Biomarker disease HPO
CUI: C4025662
Disease: Abnormality of the ulna
Abnormality of the ulna
0.100 Biomarker phenotype HPO
CUI: C4025663
Disease: Abnormality of tibia morphology
Abnormality of tibia morphology
0.100 Biomarker disease HPO
CUI: C0000822
Disease: Abortion, Tubal
Abortion, Tubal
0.300 Biomarker phenotype CTD_human Gene expression in cultured endometrium from women with different outcomes following IVF. 18539642 2008
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma
0.020 Biomarker disease BEFREE Gene expression profiles of artemin, BDNF, GDNF, TGF-beta1/beta2 and Ret were determined in the vestibular schwannoma in comparison to the peripheral nerve tissues by using semiquantitative RT-PCR. 19937367 2010
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma
0.020 Biomarker disease BEFREE The objective of the present study was to investigate the expression level and the localization of the pro-inflammatory cytokines, transforming growth factor-β1 (TGF-β1) interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α), as well as the adhesion molecules, intracellular adhesion molecule-1 and vascular endothelial growth factor (VEGF), in order to determine whether these factors are involved in the transformation and development of human vestibular schwannoma. 25738867 2015
CUI: C0271907
Disease: Acquired aplastic anemia
Acquired aplastic anemia
0.020 Biomarker disease BEFREE Subsequent in vitro experiments revealed that 1,25(OH)2 D3 treatment suppressed the proliferation of lymphocytes and inhibited the secretion of interferon-γ, tumor necrosis factor-α, and interleukin-17A, meanwhile promoting the production of transforming growth factor-β1 in patients with AA. 26152509 2016
CUI: C0271907
Disease: Acquired aplastic anemia
Acquired aplastic anemia
0.020 Biomarker disease BEFREE This initial analysis provides valuable clues for further study of TGF-β1 pathway genes in acquired AA. 27933374 2017
CUI: C0265287
Disease: Acromicric Dysplasia
Acromicric Dysplasia
0.300 Biomarker disease CTD_human ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. 18677313 2008
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.300 Biomarker disease CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.050 GeneticVariation disease BEFREE The CC genotype and the C allele of TGF-β1 might be a specific risk factor of ACS in the Chinese Han population in Xinjiang. 24737521 2014
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.050 Biomarker disease BEFREE We found ACS patients had a significantly lower frequency of circulating CD4(+)LAP(+) Tregs, and the function of these cells was reduced compared to controls. 24558424 2014
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.050 AlteredExpression disease BEFREE In contrast, Treg cell population, Foxp3 levels, and plasma TGF-β1 were decreased in ACS patients compared with stable angina (SA) and NCA patients. 21524750 2011
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.050 GeneticVariation disease BEFREE The results suggest that TGF-β1 T29C gene polymorphism could be involved in the risk of developing ACS in Mexican individuals. 22465044 2012
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.050 AlteredExpression disease BEFREE The aim was to measure the plasma levels of TGF-β1, 2, and 3 proteins in patients with ACS. 30003432 2018
CUI: C2118460
Disease: Acute colitis
Acute colitis
0.010 AlteredExpression disease BEFREE Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice. 17786278 2007
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.040 GeneticVariation disease BEFREE The aim of the present study was to evaluate the role of TGF-β1 gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS). 22465044 2012
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.040 AlteredExpression disease LHGDN Transcriptional activity of genes encoding Transforming Growth Factor beta and its receptors in peripheral blood mononuclear cells from patients with acute coronary syndromes. 16307809 2006
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.040 GeneticVariation disease BEFREE Association of a transforming growth factor-β1 polymorphism with acute coronary syndrome in a Chinese Han population. 24737521 2014
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.040 Biomarker disease BEFREE CD4(+) latency-associated peptide (LAP)(+) regulatory T cells (Tregs) are a newly discovered T cell subset in humans and the role of these cells in patients with acute coronary syndrome (ACS) has not been explored. 24558424 2014
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia
0.040 Biomarker disease BEFREE Transforming growth factor-beta 1 (TGF beta 1) can induce hemoglobin accumulation in a clone of the human HEL erythroleukemia cell line. 1895755 1991
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia
0.040 Biomarker disease BEFREE We have examined the effects of TGF beta 1 and TGF beta 2 on the HEL human erythroleukemia cell line. 2590216 1989