TGFB1, transforming growth factor beta 1, 7040

N. diseases: 1558; N. variants: 50
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype CTD_human Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells. 30809271 2019
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype CTD_human Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model. 27870162 2017
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype RGD Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle. 26923362 2016
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype CTD_human Aspidin PB, a novel natural anti-fibrotic compound, inhibited fibrogenesis in TGF-β1-stimulated keloid fibroblasts via PI-3K/Akt and Smad signaling pathways. 26054450 2015
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype CTD_human Genes involved in innate immunity associated with asbestos-related fibrotic changes. 24142982 2014
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype CTD_human Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. 18705752 2008
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 GeneticVariation phenotype LHGDN Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment. 18797412 2008
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype LHGDN Histological, immunohistochemical and biological data in assessing interstitial fibrosis in patients with chronic glomerulonephritis. 18155753 2008
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN Increased tubular C5b-9 expression may result in interstitial fibrosis through increased TGF-beta1 production. 18300128 2008
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 GeneticVariation phenotype LHGDN Transforming growth factor beta 1 gene variants increase transcription and are associated with liver cirrhosis in Chinese. 18547814 2008
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN In conclusion, an ongoing inflammatory process, the expression of TGF-beta 1, and proliferation of myofibroblasts within the valves have a potential role in the valvular fibrosis, calcification, and changes in the extracellular matrix that lead to the scarring sequelae of rheumatic heart disease. 18303197 2008
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype LHGDN The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent. 17347580 2007
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype CTD_human We show that local and transient TGF-beta1 overexpression induces homogenous, prolonged, and progressive pleural fibrosis without pleurodesis, associated with severe impairment of pulmonary function. 17947678 2007
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN We show that local and transient TGF-beta1 overexpression induces homogenous, prolonged, and progressive pleural fibrosis without pleurodesis, associated with severe impairment of pulmonary function. 17947678 2007
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN CTGF, intestinal stellate cells and carcinoid fibrogenesis. 17876891 2007
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN Cytokine production associated with periportal fibrosis during chronic schistosomiasis mansoni in humans. 16428771 2006
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype CTD_human Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium. 16306446 2006
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN TGF-beta1 expression in renal allograft rejection and cyclosporine A toxicity. 16378061 2005
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype LHGDN Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients. 16095497 2005
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN In contrast, the TGF-beta1 vector caused a more severe and prolonged inflammatory response as well as localized collagen deposition, leading to severe and progressive fibrosis. 15778431 2005
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 Biomarker phenotype LHGDN We conclude that TGF-beta1 concentration may predict the development of kidney graft fibrosis; early CsA withdrawal may achieve a reduction in chronic tubular and interstitial injury of cadaveric kidney allografts. 15848527 2005
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 GeneticVariation phenotype LHGDN Contrarily, in Caucasians TGF-beta1 allelic variations are more frequent and the presence of prolines either in codon 25 or 10 is associated with the interindividual variability in developing more severe fibrosis during chronic hepatitis C infection. 15800982 2005
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN These results show, for the first time to our knowledge, that TGF-beta1 is highly expressed in HCs and is directly involved in the pathogenesis of BM reticulin fibrosis in HCL. 14991065 2004
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 GeneticVariation phenotype LHGDN These findings support the hypothesis that angiotensin II stimulated TGF-beta1 production may promote hepatic fibrosis. 14642613 2003
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.600 AlteredExpression phenotype LHGDN These results suggest that TGF-beta(1) and PDGF expressions in bronchial mucosa may play a role in bronchial subepithelial fibrosis in EB patients. 14720431 2003