Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, interactions between VD and TGF-β1, relevant for the understanding host defense in COPD, are incompletely understood.
|
30970352 |
2020 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The plasma concentrations of IL-6, TGF-β1 and IL-12 were significantly increased in patients with COPD compared with never-smokers and smokers with normal lung function.
|
31349846 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, we propose that TGFβ1 is responsible for the generation of CD4<sup>+</sup>CD25<sup>-</sup>Foxp3<sup>+</sup> T cells, and these cells functionally exert an auxiliary effect on Th17 cells generation and might perpetuate chronic inflammation in COPD.
|
30842769 |
2019 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, compared with untreated rats with COPD, <i>C. sinensis</i> reduced the expression level of phosphorylated (p)-Smad2, p-Smad3, TGF-β1 and its receptors, with the concomitant increased expression of Smad7 in the lungs of rats with COPD.
|
29456676 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The gene expression profile indicated altered activity of upstream mediators associated with COPD pathophysiology, including hepatocyte growth factor, transforming growth factor beta 1 and platelet-derived growth factor B, which suggests that COPD-related changes in the bronchial ECM contribute to the defective regenerative ability in the airways of COPD patients.
|
29472603 |
2018 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, as a combination of tumor necrosis factor-α (TNF-α) and TGF-β1 have been shown to have a cumulative impact on the severity of airflow limitation in COPD, the TNF-α release was also measured in a representative subgroup of patients.
|
28668545 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
It has been hypothesized that polymorphisms in the transforming growth factor-β1 (<i>TGF-β1</i>) gene on chromosome 19 modify the risk for chronic obstructive pulmonary disease (COPD).
|
28784933 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
After carbachol (CCh) or transforming growth factor-β1 (TGF-β1) exposure, the response to glycopyrronium and indacaterol was determined in vitro in fibroblasts isolated from mild-to-moderate COPD lung tissue.
|
28284212 |
2017 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The FPRP test results were as follows: 1) when the prior probability was 0.001 and the OR was 1.5, ADAM33 rs612709, CHRNA3/5 rs1051730, CHRNA3/5 rs8034191, CHRNA3/5 rs16969968, and TGFB1 rs1800470 were truly associated with COPD risk (FPRP < 0.2); 2) when the prior probability was 0.000001 and the OR was 1.5, all the variants except TGFB1 rs1800470 remained noteworthy; and 3) when the probability was 0.000001 and the OR was 1.2, ADAM33 rs612709 and CHRNA3/5 rs1051730 remained true positives.
|
27323020 |
2016 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we genotyped 44 SNPs from four genes (EPHX1, GSTP1, SERPINE2, and TGFB1) in 310 patients and 203 controls which belonged to the Chinese Han population to test the two-way and three-way genetic interactions with COPD-related quantitative traits using recently developed generalized multifactor dimensionality reduction (GMDR) and quantitative multifactor dimensionality reduction (QMDR) algorithms.
|
27193053 |
2016 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The enhanced plasma BAMBI levels in COPD positively correlated with the increased plasma TGF-β1 levels and Th17/Treg ratio.
|
27549738 |
2016 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, TGF-β1 may serve as a protective factor for bronchial epithelial cell homeostasis in diseases such as COPD.
|
24358952 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
SERPINE2, FAM13A, and MMP12 associated with higher FEV1 and FVC, and SERPINE2, HHIP, and TGFB1 interacted with cigarette smoke exposure in utero in PIAMA only, showing adverse effects of exposure on FEV1 being limited to children with genotypes conferring the lowest risk of COPD.
|
23886569 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The fibroblasts that resist CSE-induced cellular senescence may contribute to the pathogenesis of idiopathic pulmonary fibrosis and could contribute to fibrotic lesions in chronic obstructive pulmonary disease acting through a TGF-β1-mediated pathway.
|
25015975 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The levels of IL-1β, TNF-α, p-NF-κB, p-IκBα, TGF-β1 and Smad2 were significantly higher in COPD rats than in controls, while they were dramatically reduced in the three TCM- and aminophylline-treated groups.
|
24766819 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of promoters of TNF-α (rs 361525 and rs 1800629) and TGF-β1 (rs 1800469) in 110 COPD patients, 110 nonsmoker health controls without COPD, and 34 smokers were evaluated.
|
24153451 |
2014 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
TGF-β1 decreased the amount of soluble FBLN-1 both from COPD and non-COPD ASM cells.
|
23762390 |
2013 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis showed that the frequencies of the GC, GT haplotypes of rs2241718 (TGF-β1 gene), and rs6957 (CDC97 gene) were significantly higher in the control group than in the COPD case group (p=1.88×10-9); the frequencies of the TT haplotype of rs1205 and rs2808630 (CRP gene) were significantly higher in the control group (p=0.0377).
|
23267696 |
2012 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study compared the expression of PI3K isoforms by ASM cells from donors with asthma (A), chronic obstructive pulmonary disease (COPD), or neither disease (NA), and investigated the role of PI3K isoforms in the production of TGFβ1 induced pro-inflammatory cytokine and contractile proteins in ASM cells.
|
22015454 |
2012 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
With respect to T869C polymorphism, a significant association of TGF-β 1 gene polymorphism at 869T/C with COPD was observed in the overall analysis (C vs. T: OR 0.82, 95%CI 0.70-0.96, P = 0.01).
|
21740629 |
2011 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association was found between TGF-β(1) gene SNPs and an increased risk of COPD in Asians.
|
21556788 |
2011 |
Chronic Obstructive Airway Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Transforming growth factor-β(1) (TGF-β(1)) is upregulated in asthma and COPD and contributes to tissue remodeling in the airways by driving ECM production by structural cells, including airway smooth muscle.
|
21908588 |
2011 |
Chronic Obstructive Airway Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that COPD lung fibroblasts have a significantly decreased response to TGF-β1 in terms of proliferation and elastin production.
|
21539942 |
2011 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Of these variants, four were significantly associated with COPD susceptibility in random effects meta-analysis, the GSTM1 null variant (OR 1.45, CI 1.09-1.92), rs1800470 in TGFB1 (0.73, CI 0.64-0.83), rs1800629 in TNF (OR 1.19, CI 1.01-1.40) and rs1799896 in SOD3 (OR 1.97, CI 1.24-3.13).
|
19933216 |
2010 |
Chronic Obstructive Airway Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism 869T/C in TGF-beta1 gene has a significant association with disease occurrence in COPD patients and the C allele might be a risk factor.
|
20193474 |
2010 |