|
Peritoneal Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results from the in vivo study showed that OA-NO2 notably relieved peritoneal fibrosis by decreasing the thickness of the peritoneum; it also inhibited the expression of TGF-β1, α-SMA, N-cadherin and vimentin and enhanced the expression of E-cadherin in the peritoneum.
|
31760768 |
2020 |
|
Peritoneal Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Because thrombospondin-1 (TSP-1) is able to activate latent TGF-β1 in vivo, we investigated whether blockade of TSP-1 could modulate mesothelial cell MMT and ameliorate peritoneal fibrosis.
|
31236971 |
2020 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Blockade of hyperglycolysis with 2-deoxyglucose (2-DG) inhibited TGF-β1-induced profibrotic cellular phenotype and peritoneal fibrosis in mice.
|
31167927 |
2019 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, there are still gaps in understanding the mechanisms underlying TGF-β1-associated EMT and peritoneal fibrosis.
|
30728376 |
2019 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Paricalcitol could be a novel approach to protect the peritoneum from the development of EMT and peritoneal fibrosis.-Ko, J., Kang, H.-J., Kim, D.-A., Ryu, E.-S., Yu, M., Lee, H., Lee, H. K., Ryu, H.-M., Park, S.-H., Kim, Y.-L., Kang, D.-H. Paricalcitol attenuates TGF-β1-induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome.
|
30354670 |
2019 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Spleen Tyrosine Kinase (SYK) in the Progression of Peritoneal Fibrosis Through Activation of the TGF-β1/Smad3 Signaling Pathway.
|
31812978 |
2019 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have found that miR-200a is down-regulated in a rat model of PD-related peritoneal fibrosis (PF) and could inhibit transforming growth factor beta 1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) in peritoneal mesothelial cells by target ZEB1/2.
|
30888602 |
2019 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor β1 (TGFβ1), through canonical and non-canonical pathways, promotes the epithelial-mesenchymal transition (EMT) process leading to PF.
|
29978330 |
2019 |
|
Peritoneal Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After inducing EMT with transforming growth factor-β1 (TGF-β1) <i>in vitro</i>, we found that miR-145 is significantly up-regulated, whereas FGF10 is markedly down-regulated, suggesting a close link between miR-145 and FGF10 in peritoneal fibrosis, further confirmed in luciferase reporter experiments.
|
31431501 |
2019 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Blocking core fucosylation dramatically attenuated peritoneal fibrosis in the rat model achieved by simultaneously inactivating the TGF-β1 and PDGF signaling pathways.
|
29571940 |
2018 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the relationship between TGF-β1 and VEGF-A in inducing peritoneal fibrosis by use of human tissues and dialysate, cultured cells, and animal models.
|
28978530 |
2018 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-β1 (TGF-β1) is a major mediator of peritoneal fibrosis and reportedly affects expression of the H3K4 methyltransferase, SET7/9.
|
29723250 |
2018 |
|
Peritoneal Fibrosis
|
0.600 |
Therapeutic
|
disease |
RGD |
Abatacept as a therapeutic option in the treatment of encapsulated peritoneal sclerosis: an experimental rat model.
|
28190234 |
2017 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We demonstrate that interfacing of the β1-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor β1 and rescues tissue integrity ex vivo and in vivo in a mouse model of peritoneal fibrosis.
|
28593951 |
2017 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results indicated that the interaction of gastric cancer with peritoneal fibrosis and determined that TGF-β1 plays a key role in induction of peritoneal fibrosis, which in turn affected dissemination of gastric cancer.
|
28092842 |
2017 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the potential role of ER stress as a target to prevent and/or delay the development of peritoneal fibrosis, we examined the effect of ER stress on EMT or apoptosis of human peritoneal mesothelial cells (HPMCs) and elucidated the mechanisms underlying the protective effect of ER stress preconditioning on TGF-β1-induced EMT.
|
26192086 |
2015 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vitro, transforming growth factor (TGF)-β1-induced EMT, identified by de novo expression of α-smooth muscle actin and a loss of E-cadherin in both human and rat peritoneal mesothelial cells, was associated with down-regulation of miR-30a but up-regulation of Snai1, suggesting a close link between miR-30a and Snai1 in TGF-β1-induced peritoneal fibrosis.
|
23831330 |
2013 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis.
|
22139024 |
2012 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Induction of gastric cancer cell adhesion through transforming growth factor-beta1-mediated peritoneal fibrosis.
|
21034459 |
2010 |
|
Peritoneal Fibrosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Inhibition of TGF-beta1 expression in human peritoneal mesothelial cells (HPMC) may provide a potential treatment for PF.
|
17199790 |
2006 |
|
Peritoneal Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that a progressive decrease of the CD4/CD8 ratio in PDE correlates with a persistent expression of TGF-beta1, and plays a pathogenetic role in the evolution of peritonitis, PET deterioration and peritoneal fibrosis.
|
12748353 |
2003 |
|
Peritoneal Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In an attempt to search for a factor related to PF, we designed a longitudinal study to measure TGF-beta1 levels in dialysate and TGF-beta1 mRNA expression in peritoneal mononuclear cells from peritoneal dialysate before onset, once a week during peritonitis, and after peritonitis in high and low peritonitis occurrence (HPO and LPO) patients.
|
9845827 |
1998 |