Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells.
|
16489022 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results of the present study suggest that TGFBI-promoted metastasis of RCC cells depends on inactivation of the VHL tumor suppressor and that TGFBI could be a therapeutic target against RCC in the future.
|
22341602 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transforming growth factor β‑induced (TGFBI) has been implicated as a tumor suppressor, which enhances gemcitabine chemosensitivity in lung cancer cells.
|
26503734 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We then used the MTg-AMO approach to identify several tumor suppressors-TGFBI, APC and BCL2L11 as the target genes for oncogenic miR-21, miR-155 and miR-17-5p, respectively, and two cardiac ion channel genes HCN2 (encoding a subunit of cardiac pacemaker channel) and CACNA1C (encoding the alpha-subunit of cardiac L-type Ca(2+) channel) for the muscle-specific miR-1 and miR-133.
|
19136465 |
2009 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It was found that the positive ratio of βig-h3 in the gastric cancer group was higher than that in the benign disease group, and the positive rate of immunohistochemistry was closely related to the relative factors of peritoneal metastasis such as tumor infiltration depth, serosal types, macroscopic peritoneal metastasis, CEA mRNA, results of pleural lavage cytology (PLC) examination, etc.
|
25864756 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our findings demonstrate that TGFBIp is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis.
|
25772247 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TGFBI, a secreted protein that is induced by transforming growth factor-β in various human cell types, has been shown to be associated with tumorigenesis in various types of tumors.
|
21701776 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, we found that targeting βig-h3 in established lesions released the tissue tension and functionally reprogrammed F4/80 macrophages in the tumour microenvironment.
|
30415234 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The observations that TGFBI knock-out animals showed increased spontaneous tumor incidence and chemically induced tumors highlight the suppressive nature of the gene.
|
21901626 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these data suggest that BIGH3 acts as a tumor suppressor in the retina.
|
28099942 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is known that βig-h3 is involved in the invasive process of many types of tumors, but its mechanism in glioma cells has not been fully clarified.
|
22629380 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When 95 high-grade serous EOCs were grouped by genes based on ANOVA comparing ESR1/WT1 and POSTN/TGFBI samples, overall survival (OS) was significantly shorter for 43 patients with tumors expressing genes associated with POSTN/TGFBI compared to 52 patients with tumors expressing genes associated with ESR1/WT1 (median 30 versus 49 months, respectively; P = 0.022).
|
24368280 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transforming growth factor β-induced (TGFBI) protein is a secreted extracellular matrix protein with conflicting roles in cancer, acting as a tumour suppressor and a promoter, which appears to be tissue specific.
|
30260476 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias.
|
24791868 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By contrast, the expanding control tumors showed intense TGFBI staining at the tumor edges, co-localizing with the fibrillar fibronectin/tenascin-C/periostin structures that characteristically surround melanoma cells at invasion fronts.
|
22326753 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Identification and characterization of transforming growth factor beta-induced in circulating tumor cell subline from pancreatic cancer cell line.
|
30156359 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Besides, the xenograft animal study showed that TGFBI knockout suppressed tumor growth and metastasis in vivo.
|
31598162 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk1.
|
31094056 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The findings provide strong evidence that the Betaig-h3 gene has tumour suppressor function in human BEP2D cell model and suggest a potential target for interventional therapy.
|
12085188 |
2002 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results support the theory that TGFBI acts as a potent endogenous anti-tumor and anti-angiogenic molecule by targeting αvβ3 integrin, and highlights the importance of physiological circulating TGFBI levels in inhibiting tumor growth.
|
23792174 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu.
|
25284464 |
2015 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Dense methylation of the TGFBI promoter correlated with the extent of TGFBI gene silencing in tumor cell lines and was related to invasiveness of prostate tumors and metastatic status of lung cancer tumors.
|
18834524 |
2008 |
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
TGFBI methylation was observed in 23 out of 38 (60.5%) cases of ovarian cancer, in no normal ovarian tissues (0 of 38, P=0.001), and in 5 out of 18 (27.8%) borderline tumors (P=0.044).
|
20421128 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant association was found between the presence of TGFBI expression with tumor category T3-4 (P<0.0001), Fuhrman grades III and IV (P<0.0001), tumor size>4cm (P<0.0001), presence of tumor necrosis (P<0.0001), nodal involvement (n = 0.009), metastasis (P = 0.012), SSIGN score≥5 (P<0.0001), cancer progression (P<0.0001), and cancer-specific death (P<0.0001).
|
25035170 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
BXPC3 tumor xenografts demonstrated reduced growth with DDR1 knockdown, and the same xenograft tumors exhibited an increase in TGFBI expression level.
|
25369402 |
2014 |