|
Nasopharyngeal carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Transforming growth factor-beta-induced (TGFBI) is an exocrine protein, which has been found to be able to promote the development of nasopharyngeal carcinoma, glioma, pancreatic cancer, and other tumors.
|
31440088 |
2019 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Transforming growth factor-beta-induced (TGFBI) is an exocrine protein, which has been found to be able to promote the development of nasopharyngeal carcinoma, glioma, pancreatic cancer, and other tumors.
|
31440088 |
2019 |
|
Squamous cell carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusions</b>: TGFBI overexpression can promote OSCC and is associated with poor prognosis in OSCC patients.
|
31598162 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
<sup>1</sup> has identified a novel androgen-mediated signaling axis driven by loss of SPDEF and gain of TGFBI to facilitate metastasis, which may explain the acquisition of resistance to androgen deprivation therapy.
|
29757697 |
2018 |
|
Corneal guttata
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Corneal guttata associated with the corneal dystrophy resulting from a betaig-h3 R124H mutation.
|
10611102 |
2000 |
|
Avellino corneal dystrophy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Avellino corneal dystrophy (ACD) is a common corneal dystrophy that shows allelic homogeneity, R124H mutation in the transforming growth factor beta-induced (TGFBI) gene.
|
17096061 |
2007 |
|
Avellino corneal dystrophy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Granular corneal dystrophy type II (GCD II) is an autosomal dominant disorder characterized by age-dependent progressive accumulation of transforming growth factor-beta-induced protein (TGFBIp) deposits in the corneal stroma.
|
19497990 |
2009 |
|
Familial Amyloid Polyneuropathy, Type V
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lattice corneal dystrophy type IV (p.Leu527Arg) is caused by a founder mutation of the TGFBI gene in a single Japanese ancestor.
|
20357204 |
2010 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Melanomas without chronic sun-induced damage (Non-CSD) were more likely (P<0.01) to show BRAF mutations while NRAS mutation frequency was unbiased between melanoma subtypes.
|
21788131 |
2012 |
|
Avellino corneal dystrophy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Granular corneal dystrophy type 2 (GCD2) is an autosomal dominant disease caused by a R124H point mutation in the transforming growth factor-β-induced gene (TGFBI).
|
22374302 |
2012 |
|
Corneal dystrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Corneal dystrophy-related mutations are more likely to disrupt the interaction of TGFBI with critical binding proteins than affect the whole protein structure.
|
22605926 |
2012 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cancer-specific survival was significantly better for patients with no cytoplasmic TGFBI expression (1-, 3-, 5-y cancer-specific survival of 94.7%, 87.8%, and 73.4% vs. 92.9%, 71.2%, and 49.8%, respectively; P<0.0001).
|
25035170 |
2015 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Cancer-specific survival was significantly better for patients with no cytoplasmic TGFBI expression (1-, 3-, 5-y cancer-specific survival of 94.7%, 87.8%, and 73.4% vs. 92.9%, 71.2%, and 49.8%, respectively; P<0.0001).
|
25035170 |
2015 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Renal fibrosis in nephrectomized rats and profibrotic transforming growth factor-β-induced epithelial-mesenchymal transition (EMT) and ERK1/2 activation in NRK-52E cells were suppressed by sh-periostin.
|
31127625 |
2019 |
|
Unspecified visual loss
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Visual loss is significantly greater in CDB I, and recurrences after keratoplasty or keratectomy seem to be earlier and more extensive in CDB I.
|
7671605 |
1995 |
|
Lattice corneal dystrophy Type I
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Lattice corneal dystrophy type 1 in a Canadian kindred is associated with the Arg124 --> Cys mutation in the kerato-epithelin gene. sgupta@ogh.on.ca.
|
9559741 |
1998 |
|
Corneal dystrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
BIGH3 exon 14 mutations lead to intermediate type I/IIIA of lattice corneal dystrophies.
|
10798644 |
2000 |
|
Corneal dystrophy
|
0.200 |
Biomarker
|
disease |
BEFREE |
BIGH3 gene analysis in the differential diagnosis of corneal dystrophies.
|
11189007 |
2001 |
|
Colon adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
|
11196171 |
2001 |
|
Kidney Diseases
|
0.210 |
AlteredExpression
|
group |
BEFREE |
Beta(ig)-H3 protein expression was identified in distal convoluted tubular epithelium and parietal glomerular epithelium in CyAN, and not in nephrectomy samples.
|
11740395 |
2001 |
|
Corneal dystrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
BetaIG-H3 is a TGF-beta-induced cell adhesion molecule, the mutations of which are responsible for a group of 5q31-linked corneal dystrophies.
|
11867580 |
2002 |
|
Corneal dystrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
BIGH3 mutation spectrum in corneal dystrophies.
|
11923233 |
2002 |
|
Reis-Bucklers' corneal dystrophy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Transforming growth factor beta induced protein accumulation in granular corneal dystrophy type III (Reis-Bücklers dystrophy). Identification by mass spectrometry in 15 year old two-dimensional protein gels.
|
12942051 |
2003 |
|
Hereditary corneal dystrophy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
TGFBI gene mutation analysis in families with hereditary corneal dystrophies from Ukraine.
|
15564760 |
2005 |
|
Corneal dystrophy
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TGFBI gene mutations causing lattice and granular corneal dystrophies in Indian patients.
|
15623763 |
2005 |