|
Arteriovenous fistula
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
At day 3, female AVF had significantly higher average gene expression of TGF-β1 and TGFβ-R1 compared to male.
|
31813252 |
2020 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, TGFBR1 overexpression rescues effects of miR-27a inhibitor on DLBCL cells phenotypes.
|
31797450 |
2020 |
|
Malignant neoplasm of mouth
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This preliminary prospective study suggests that polymorphism of TGFBR1 rs334348 may act as a potentially independent factor and novel genetic biomarker to predict oral cancer DSS especially for patients with radiotherapy.
|
31651066 |
2020 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This preliminary prospective study suggests that polymorphism of TGFBR1 rs334348 may act as a potentially independent factor and novel genetic biomarker to predict oral cancer DSS especially for patients with radiotherapy.
|
31651066 |
2020 |
|
Rotator cuff syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In males, the A allele of COL5A1 rs3196378 (p = 0.032) and the G allele of TGFBR1 rs1590 (p = 0.039) were independent risk factors for RCT.
|
31444797 |
2020 |
|
Chronic thromboembolic pulmonary hypertension
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased circulating active TGFβ1 levels, endothelial TGFβRI/ALK1 and TGFβRI/ALK5 expression were detected in End.TGFβRII-KO mice, and activated TGFβ signaling was present in vessel-rich areas of CTEPH specimens.
|
31747868 |
2020 |
|
Pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-181b-5p inhibits endothelial-mesenchymal transition in monocrotaline-induced pulmonary arterial hypertension by targeting endocan and TGFBR1.
|
31734320 |
2020 |
|
Idiopathic pulmonary arterial hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, our findings firstly demonstrate that the beneficial effect of miR-181b on PAH may be associated with endocan/TGFBR1-mediated EndMT, providing a new insight into the diagnosis and treatment of PAH.
|
31734320 |
2020 |
|
Carcinosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to assess the activity of fucoidan on the uterine sarcomas (MES-SA and ESS-1) and carcinosarcoma cell lines (SK-UT-1 and SK-UT-1B) and its toxicity on the human skin fibroblasts (HSF).
|
30659312 |
2019 |
|
Osteopenia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further, when injected <i>in vivo</i>, agomiR-let-7f-5p significantly reversed bone loss induced by Dex, as well as increased osteogenic marker expression (<i>Runx2</i>, <i>Osx</i>, <i>Alp</i>, and <i>Ocn</i>) and decreased TGFBR1 expression in bone extracts.
|
31592234 |
2019 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicated that the regulatory axis of GR/let-7f-5p/TGFBR1 may be important for Dex-inhibited osteoblast differentiation and that let-7f-5p may be a useful therapeutic target for GIOP.
|
31592234 |
2019 |
|
Peyronie Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In view of the critical role of TGF-β and the Smad pathway in the pathogenesis of PD, inhibition of this pathway with an ALK5 inhibitor may represent a novel, targeted therapy for PD.
|
31496148 |
2019 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these results indicated that ALK-5 inhibitors might affect lung fibrosis mainly via the inhibition of MTD.
|
30448291 |
2019 |
|
Solid Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study.
|
31300967 |
2019 |
|
MRSA - Methicillin resistant Staphylococcus aureus infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Implants in this study were exposed to MRSA (ATCC43300), P. aeruginosa (ATCC27853), MSSE (ATCC35984), and Candida Albicans (ATCC10231).
|
30409704 |
2019 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
First, ALK5 expression was significantly increased in middle cerebral artery occlusion/reperfusion (MCAO/R) rats.
|
31043581 |
2019 |
|
Metastatic Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma.
|
30655341 |
2019 |
|
Unresectable Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A phase 1b study of transforming growth factor-beta receptor I inhibitor galunisertib in combination with sorafenib in Japanese patients with unresectable hepatocellular carcinoma.
|
29995286 |
2019 |
|
Endometrial adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we present a mouse model with conditional inactivation of activin receptor-like kinase 5 (ALK5) in the mouse uterus using progesterone receptor cre ("<i>Alk5</i> cKO") that develops endometrial adenocarcinoma with metastasis to the lungs.
|
30655341 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To further evaluate PCLS as an in vitro model, we have tested ALK5 inhibitor SB525334 which was previously shown to attenuate fibrosis in in vivo bleomycin model and nintedanib which is the FDA approved treatment for IPF.
|
30776489 |
2019 |
|
CHROMATE RESISTANCE (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Shewanella decolorationis LDS1 Chromate Resistance.
|
31300400 |
2019 |
|
Molar Incisor Hypomineralization
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This family-based study demonstrated an association between variation in TGFBR1 and MIH.
|
30130760 |
2019 |
|
PARKINSON DISEASE, LATE-ONSET
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Injection of macrophage clean reagent and ω-3PUFA significantly inhibited M2 activation, and decreased Masson staining, α-SMA, TGF-β1, VEGF and ALK5 protein expression in peritoneal tissues in PD treated rats.
|
30887626 |
2019 |
|
Carpal Tunnel Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together the inhibition of TβRI appears to be the primary mediator of fibrotic gene expression in fibroblasts from CTS patients.
|
28294324 |
2018 |
|
granulosa cell tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs.
|
29788434 |
2018 |