|
Inflammatory Bowel Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Total CD3 T Cells Are Necessary and Sufficient to Induce Colitis in Immunodeficient Mice With Dendritic Cell-Specific Deletion of TGFbR2: A Novel IBD Model to Study CD4 and CD8 T-Cell Interaction.
|
31559420 |
2020 |
|
Irritable Bowel Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Total CD3 T Cells Are Necessary and Sufficient to Induce Colitis in Immunodeficient Mice With Dendritic Cell-Specific Deletion of TGFbR2: A Novel IBD Model to Study CD4 and CD8 T-Cell Interaction.
|
31559420 |
2020 |
|
Adenocarcinoma of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two triplets (MIR22HG_hsa-mir-21_TGFBR2 and MIR22HG_hsa-mir-21_BCL2) were finally identified; not only were they significantly associated with PRAD survival but they also had the highest average degree in the identified subnetwork.
|
31579415 |
2019 |
|
Hepatic Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
C57Bl/6 or neuron-specific transforming growth factor beta receptor 2 (TGFβR2) null mice (TGFβR2<sup>ΔNeu</sup>) were treated with azoxymethane (AOM) to induce acute liver failure and HE.
|
30940161 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Methods</b>: We established a cisplatin-induced AKI mouse model with TGF-β type II receptor or Smad2 specifically deleted from renal tubular epithelial cells (TECs).
|
31754396 |
2019 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we developed gene therapies based on 3 longevity associated genes (fibroblast growth factor 21 [FGF21], αKlotho, soluble form of mouse transforming growth factor-β receptor 2 [sTGFβR2]) delivered using adeno-associated viruses and explored their ability to mitigate 4 age-related diseases: obesity, type II diabetes, heart failure, and renal failure.
|
31685628 |
2019 |
|
Kidney Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we developed gene therapies based on 3 longevity associated genes (fibroblast growth factor 21 [FGF21], αKlotho, soluble form of mouse transforming growth factor-β receptor 2 [sTGFβR2]) delivered using adeno-associated viruses and explored their ability to mitigate 4 age-related diseases: obesity, type II diabetes, heart failure, and renal failure.
|
31685628 |
2019 |
|
Liver Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
C57Bl/6 or neuron-specific transforming growth factor beta receptor 2 (TGFβR2) null mice (TGFβR2<sup>ΔNeu</sup>) were treated with azoxymethane (AOM) to induce acute liver failure and HE.
|
30940161 |
2019 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
While retinal vasculature was unaffected, TGFBR2-deficient microglia demonstrated exaggerated responses to laser-induced injury that was associated with increased choroidal neovascularization, a hallmark of advanced exudative AMD.
|
30666961 |
2019 |
|
Drug-Induced Liver Disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury.
|
31534460 |
2019 |
|
Luminal A Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Logistic models including TGFB1 variants showed that in luminal-A tumors, G-875A retained its significance while TGFB1 haplotype showed a trend towards significance; otherwise, in HER2<sup>+</sup> tumors TGFB1 variants remained significant while TGFBR2 showed a trend for association.
|
31364002 |
2019 |
|
Extrahepatic Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although the lack of an appropriate mouse model has hampered investigation of extrahepatic cholangiocarcinoma (ECC), we recently established a novel mouse model of biliary injury-related ECC by ductal cell-specific activation of Kras and deletion of transforming growth factor (TGF) β receptor type 2 and E-cadherin.
|
30536105 |
2019 |
|
Developmental Coordination Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study examined 23 children (group 1), aged 4-13 years, with different HCTDs (i.e., 19 with hypermobile Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorder, 3 with molecularly confirmed classical EDS, and 1 with Loeys-Dietz syndrome type 1 due to TGFBR2 mutation) and 23, age- and sex-matched children with DCD (group 2).
|
30070022 |
2018 |
|
Hodgkin Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Materials and Methods In a dose escalation study, eight patients with Epstein Barr virus-positive Hodgkin lymphoma received two to 12 doses of between 2 × 10<sup>7</sup> and 1.5 × 10<sup>8</sup> cells/m<sup>2</sup> of DNRII-expressing T cells with specificity for the Epstein Barr virus-derived tumor antigens, latent membrane protein (LMP)-1 and LMP-2 (DNRII-LSTs).
|
29315015 |
2018 |
|
Dental Fluorosis, Acquired
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, present investigation is a first attempt to link fluoride induced hyper H3K9 tri-methylation mediated repression of TGFBR2 and SMAD3 with the development of skeletal fluorosis.
|
29275289 |
2018 |
|
Adult Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Materials and Methods In a dose escalation study, eight patients with Epstein Barr virus-positive Hodgkin lymphoma received two to 12 doses of between 2 × 10<sup>7</sup> and 1.5 × 10<sup>8</sup> cells/m<sup>2</sup> of DNRII-expressing T cells with specificity for the Epstein Barr virus-derived tumor antigens, latent membrane protein (LMP)-1 and LMP-2 (DNRII-LSTs).
|
29315015 |
2018 |
|
Childhood Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Materials and Methods In a dose escalation study, eight patients with Epstein Barr virus-positive Hodgkin lymphoma received two to 12 doses of between 2 × 10<sup>7</sup> and 1.5 × 10<sup>8</sup> cells/m<sup>2</sup> of DNRII-expressing T cells with specificity for the Epstein Barr virus-derived tumor antigens, latent membrane protein (LMP)-1 and LMP-2 (DNRII-LSTs).
|
29315015 |
2018 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To better model the primarily luminal phenotype of human CaP we mutated Pten and Tgfbr2 specifically in luminal cells, and found that these tumors also progress to invasive and metastatic cancer.
|
29782499 |
2018 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our findings demonstrated that increased TGFBR2 could be responsible for the hyperactive TGF-β signaling observed in SSc.
|
30145936 |
2018 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tgfbr2 ablation late in the pathological process reduced cardiac fibrosis, preserved cardiac function, and prolonged Mybpc3<sup>40kDa</sup> mouse survival but failed to reverse cardiac hypertrophy.
|
30566042 |
2018 |
|
Hippocampal sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The increase in protein expression level of the ligand TGFβ1 was 285 ± 1.15% higher and its receptor TGFβRII was 170 ± 0.98% higher in hippocampus of patients with HS in comparison to the autopsy hippocampal control samples.
|
30153648 |
2018 |
|
Progression of prostate cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, we conducted PCR, western blot, and luciferase assays which studied the relationship of miR-93 and TGFBR2 in PCa cell lines and specimens.
|
29699590 |
2018 |
|
Loeys-Dietz Syndrome Type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study examined 23 children (group 1), aged 4-13 years, with different HCTDs (i.e., 19 with hypermobile Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorder, 3 with molecularly confirmed classical EDS, and 1 with Loeys-Dietz syndrome type 1 due to TGFBR2 mutation) and 23, age- and sex-matched children with DCD (group 2).
|
30070022 |
2018 |
|
Cerebral hemorrhage with amyloidosis, hereditary, Dutch type
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TGFβ1 and TGFβ Receptor 2 (TGFBR2) gene expression levels were significantly increased in HCHWA-D in comparison to the controls, in both frontal and occipital lobes.
|
28557134 |
2018 |
|
Autoimmune cholangitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type II (dnTGFβRII) spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis (PBC).
|
29375127 |
2018 |