Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, GTF2IRD1 promoted CRC progression by downregulating TGFβR2 and could be a prognostic biomarker on Ch.7q in CRC.
|
31758608 |
2020 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TGF-β receptor type 2 (<i>TGFBR2</i>) mutations affected by a mismatch repair deficiency causes colorectal cancers (CRCs) with microsatellite instability, which is, however, associated with relatively better survival rates.
|
31756952 |
2019 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MicroRNA-3191 promotes migration and invasion by downregulating TGFBR2 in colorectal cancer.
|
30770602 |
2019 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
TGFBR2-deficient CRCs present altered target gene and protein expression.
|
31454892 |
2019 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TGFBR2‑dependent alterations of microRNA profiles in extracellular vesicles and parental colorectal cancer cells.
|
31432155 |
2019 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
EGFR, SMAD7, and TGFBR2 are associated with CRC risk in patients with Lynch syndrome.
|
30275229 |
2018 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also detected two novel candidate CRC risk variants (rs13075948 and rs17025857) in TGFBR2, a gene known to be associated with CRC risk.
|
29986644 |
2018 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The SB transposon system provides an unbiased method to identify Tgfbr2 cooperating genes in mouse CRC that are functionally relevant and that may provide further insight into the pathogenesis of human CRC.
|
27790711 |
2017 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
TGFBR2-dependent effects on the cargo and functions of exosomes were studied in a MSI CRC model cell line enabling reconstituted and inducible TGFBR2 expression and signaling.
|
28376875 |
2017 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, GSDMC was upregulated by TGFBR2 mutation in CRC and promoted tumor cell proliferation in CRC carcinogenesis, suggesting that GSDMC may be a promising therapeutic target.
|
27835699 |
2016 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we investigated in a more systematic approach, expression changes of TGFBR2-regulated genes, involved in glycosylation using a TGFBR2-reconstituted colorectal cancer cell line (HCT116-TGFBR2) and Glyco-Gene Chip analysis.
|
27156840 |
2016 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that the TGFBR2 protein levels were consistently upregulated in CRC tissues, whereas its mRNA levels varied in these tissues, suggesting that a post-transcriptional mechanism is involved in the regulation of TGFBR2.
|
26061281 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.
|
25736321 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we observed differences in MSH3 and TGFBR2 mutational frequency between Lynch syndrome and sporadic MSI CRC regarding tumour location.
|
26247575 |
2015 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MicroRNA-200b stimulates tumour growth in TGFBR2-null colorectal cancers by negatively regulating p27/kip1.
|
24151081 |
2014 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consequently, we determined in vivo if deregulation of these two pathways cooperates to affect CRC formation by analyzing tumors arising in mice that lack Tgfbr2 and/or Pten specifically in the intestinal epithelium.
|
23604118 |
2014 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Colorectal cancers (CRCs) frequently harbor somatic mutations in the pathway members TGFBR2 and SMAD4, but to what extent mutations in SMAD2 or SMAD3 contribute to tumorigenesis is unclear.
|
23139211 |
2013 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
About 15% of CRC show the microsatellite instability (MSI) phenotype that is associated with a high frequency of biallelic frameshift mutations in the A10 coding mononucleotide microsatellite of the transforming growth factor beta receptor 2 (TGFBR2) gene.
|
23468914 |
2013 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MiR-106a inhibits the expression of transforming growth factor-β receptor 2 (TGFBR2), leading to increased CRC cell migration and invasion.
|
22912877 |
2012 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, a role of TGFBR2 or BAX mononucleotide mutation in colorectal cancer as a prognostic biomarker remains uncertain.
|
21949851 |
2011 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type II as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis.
|
21362268 |
2011 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
5-ASA increases replication fidelity in mononucleotide, dinucleotide, and tetranucleotide repeats and reduces mutations in tumor suppressor genes TGFBR2 and ACVR2, a finding that may provoke in vivo studies for the prevention of colorectal cancer in hereditary nonpolyposis colorectal cancer.
|
20197483 |
2010 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability.
|
20565851 |
2010 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine whether the epithelial to mesenchymal transition (EMT) is impaired in MSI-positive CRCs that characteristically have a mutant transforming growth factor-beta receptor type II (TGFBR2) gene.
|
20026115 |
2010 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The carcinogenesis process in ulcerative colitis-associated colorectal cancer was closely associated with the microsatellite instability pathway through TGFbetaRII mutation by a dysfunction of the mismatch repair system.
|
18546042 |
2008 |