Disease: Colorectal Cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 Biomarker disease BEFREE TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. 28376875 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 AlteredExpression disease BEFREE Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1. 27156840 2017
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 Biomarker disease BEFREE miR-135b Promotes Cancer Progression by Targeting Transforming Growth Factor Beta Receptor II (TGFBR2) in Colorectal Cancer. 26061281 2016
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2. 25736321 2015
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 Biomarker disease BEFREE MicroRNA-200b stimulates tumour growth in TGFBR2-null colorectal cancers by negatively regulating p27/kip1. 24151081 2014
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 Biomarker disease BEFREE Consequently, we determined in vivo if deregulation of these two pathways cooperates to affect CRC formation by analyzing tumors arising in mice that lack Tgfbr2 and/or Pten specifically in the intestinal epithelium. 23604118 2014
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 Biomarker disease BEFREE Transforming growth factor beta receptor 2 (TGFBR2) changes sialylation in the microsatellite unstable (MSI) Colorectal cancer cell line HCT116. 23468914 2013
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 AlteredExpression disease BEFREE MiR-106a inhibits the expression of transforming growth factor-β receptor 2 (TGFBR2), leading to increased CRC cell migration and invasion. 22912877 2013
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE Colorectal cancers (CRCs) frequently harbor somatic mutations in the pathway members TGFBR2 and SMAD4, but to what extent mutations in SMAD2 or SMAD3 contribute to tumorigenesis is unclear. 23139211 2013
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE TGFBR2 or BAX mononucleotide mutations are not associated with the patient survival outcome in MSI-high colorectal cancer. 21949851 2012
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE Mutations in TGFbeta-RII and BAX mediate tumor progression in the later stages of colorectal cancer with microsatellite instability. 20565851 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE 5-ASA increases replication fidelity in mononucleotide, dinucleotide, and tetranucleotide repeats and reduces mutations in tumor suppressor genes TGFBR2 and ACVR2, a finding that may provoke in vivo studies for the prevention of colorectal cancer in hereditary nonpolyposis colorectal cancer. 20197483 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE We sought to determine whether the epithelial to mesenchymal transition (EMT) is impaired in MSI-positive CRCs that characteristically have a mutant transforming growth factor-beta receptor type II (TGFBR2) gene. 20026115 2010
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE The carcinogenesis process in ulcerative colitis-associated colorectal cancer was closely associated with the microsatellite instability pathway through TGFbetaRII mutation by a dysfunction of the mismatch repair system. 18546042 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE IGFBP3 promoter methylation may occur in colorectal cancer with or without the CpG island methylator phenotype (CIMP), which is associated with microsatellite instability (MSI) and TGFBR2 mutation. 18084616 2008
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. 17270239 2007
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE Specifically, TGFBR2 and ACVR2 mutations are significantly rarer in MSI-H IBDNs than in MSI-H sporadic CRCs. 16012936 2005
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 Biomarker disease BEFREE Loss of activin signaling through mutation of ACVR2, similar to observations with TGFBR2, may be important in the genesis of MSI-H colorectal cancer. 14988818 2004
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE We exploited a fortuitous experiment of nature to directly test this hypothesis: the TGF-beta type II receptor gene is inactivated by mutation in nearly all colorectal carcinomas having microsatellite instability, as seen in hereditary nonpolyposis colorectal cancer (HNPCC) and in sporadic medullary colorectal cancers. 11159190 2001
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE We investigated the role of TGFBR2 mutations in 12 colorectal cancer cell lines. 10077641 1999
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE We then compared colorectal cancers with 'mild' RER (n = 15), and those with 'severe' RER without (n = 11) or with (n = 22) detectable mutations in MSH2 or MLH1 to assess the involvement of mononucleotide repeats contained in the coding regions of MSH3, MSH6, BAX, and TGFbeta RII. 9674699 1998
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 Biomarker disease BEFREE We developed a method to analyze a polyadenine tract, the (A)10 repeat, within the cysteine-rich domain of the transforming growth factor-beta (TGF-beta) type II receptor gene using a non-gel-sieving capillary electrophoresis technique and applied it to the DNA diagnosis of colorectal cancers. 9166228 1997
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE RER was found in 17 cases (4 with gastric, 12 with colorectal, and 1 with gallbladder cancer), and 10 of those (3 with gastric and 7 with colorectal cancer) showed mutations of the RII gene. 8971166 1997
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication error-positive colorectal cancer patients is mutation of the poly A tract of the transforming growth factor-beta receptor type II (RII) gene resulting in the generation of a premature STOP codon. 8868100 1996
CUI: C1527249
Disease: Colorectal Cancer
Colorectal Cancer 		0.400 GeneticVariation disease BEFREE Escape from negative growth regulation by transforming growth factor beta (TGF-beta) as a result of the loss of TGF-beta type II receptor (RII) expression has been found to be associated with the replication error (RER) colorectal cancer genotype, which is characteristic of hereditary nonpolyposis colorectal cancers. 7665626 1995